DegronMD

Uniprot ID: Q8IV53

Source protein: DENN domain-containing protein 1C

Source gene: DENND1C

Class: DEG_SCF_FBW7_1

Location: 699:704

E3 ligase: FBXW7

DEGRON score: 0.9103

ASA_SCORE: 78.7667

COIL: 0.8532

CONS_SCORE: 0.3177

DSS_SCORE: 0.7784

HELIX: 0.1053

FCONS_SCORE: 1.0169

RIG_SCORE: 0.638

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E697K	TCGA-B0-5701	KIRC	TCGA	PTPWLS	DEG_SCF_FBW7_1	0.2778
p.E697K	TCGA-DA-A1IC	SKCM	TCGA	PTPWLS	DEG_SCF_FBW7_1	0.2778
p.E697K	DO16240	KIRC	ICGC	PTPWLS	DEG_SCF_FBW7_1	0.2778
p.E697K	DO229054	LICA	ICGC	PTPWLS	DEG_SCF_FBW7_1	0.2778
p.E697K	DO37430	SKCM	ICGC	PTPWLS	DEG_SCF_FBW7_1	0.2778
p.S704Y	TCGA-BK-A139	UCEC	TCGA	PTPWLS	DEG_SCF_FBW7_1	0.712
p.S704Y	DO41716	UCEC	ICGC	PTPWLS	DEG_SCF_FBW7_1	0.712
p.S693Y	TCGA-D1-A103	UCEC	TCGA	PTPWLS	DEG_SCF_FBW7_1	0.1667
p.S693Y	DO42312	UCEC	ICGC	PTPWLS	DEG_SCF_FBW7_1	0.1667
p.A689T	TCGA-D3-A1Q4	SKCM	TCGA	PTPWLS	DEG_SCF_FBW7_1	0.0556
p.A689T	DO47631	SKCM	ICGC	PTPWLS	DEG_SCF_FBW7_1	0.0556
p.T700I	TCGA-IB-7651	PAAD	TCGA	PTPWLS	DEG_SCF_FBW7_1	0.7078
p.A689E	DO228976	LICA	ICGC	PTPWLS	DEG_SCF_FBW7_1	0.0556
p.A706E	DO229018	LICA	ICGC	PTPWLS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IV53	DENN domain-containing protein 1C	DEG_SCF_FBW7_1	699:704	PTPWLS	FBXW7	0.9103	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons