DegronMD - Q6ZN16(MAP3K15)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F862L	TCGA-06-5416	GBM	TCGA	FKIHPE	LIG_APCC_ABBA_1	867:872	Mutation rewiring degron network	0.1944
p.F862L	DO10880	GBM	ICGC	FKIHPE	LIG_APCC_ABBA_1	867:872	Mutation rewiring degron network	0.1944
p.R882Q	TCGA-44-7670	LUAD	TCGA	FKIHPE	LIG_APCC_ABBA_1	867:872	Mutation rewiring degron network	0.0556
p.R882Q	DO23555	LUAD	ICGC	FKIHPE	LIG_APCC_ABBA_1	867:872	Mutation rewiring degron network	0.0556
p.P940S	TCGA-A5-A0G1	UCEC	TCGA	ATSSS	DEG_SPOP_SBC_1	942:946	Mutation rewiring degron network	0.2778
p.P940S	DO42472	UCEC	ICGC	ATSSS	DEG_SPOP_SBC_1	942:946	Mutation rewiring degron network	0.2778
p.Q858H	TCGA-A5-A1OF	UCEC	TCGA	FKIHPE	LIG_APCC_ABBA_1	867:872	Mutation rewiring degron network	0.0833
p.Q858H	DO42568	UCEC	ICGC	FKIHPE	LIG_APCC_ABBA_1	867:872	Mutation rewiring degron network	0.0833
p.P857L	TCGA-A5-A1OF	UCEC	TCGA	FKIHPE	LIG_APCC_ABBA_1	867:872	Mutation rewiring degron network	0.0556
p.P857L	DO42568	UCEC	ICGC	FKIHPE	LIG_APCC_ABBA_1	867:872	Mutation rewiring degron network	0.0556
p.R967L	TCGA-AJ-A3EL	UCEC	TCGA	PRHHLGHLL	DEG_APCC_DBOX_1	969:977	Mutation rewiring degron network	0.2778
p.R967L	DO41542	UCEC	ICGC	PRHHLGHLL	DEG_APCC_DBOX_1	969:977	Mutation rewiring degron network	0.2778
p.V864L	TCGA-AJ-A3EL	UCEC	TCGA	FKIHPE	LIG_APCC_ABBA_1	867:872	Mutation rewiring degron network	0.25
p.P980T	TCGA-AX-A2HC	UCEC	TCGA	PRHHLGHLL	DEG_APCC_DBOX_1	969:977	Mutation rewiring degron network	0.25
p.P980T	DO41572	UCEC	ICGC	PRHHLGHLL	DEG_APCC_DBOX_1	969:977	Mutation rewiring degron network	0.25
p.P953L	TCGA-C5-A7UE	CESC	TCGA	ATSSS	DEG_SPOP_SBC_1	942:946	Mutation rewiring degron network	0.1389
p.P953L	DO49890	CESC	ICGC	ATSSS	DEG_SPOP_SBC_1	942:946	Mutation rewiring degron network	0.1389
p.E982K	TCGA-CD-5804	STAD	TCGA	PRHHLGHLL	DEG_APCC_DBOX_1	969:977	Mutation rewiring degron network	0.1944
p.E982K	DO38583	STAD	ICGC	PRHHLGHLL	DEG_APCC_DBOX_1	969:977	Mutation rewiring degron network	0.1944
p.A961T	TCGA-D5-6928	COAD	TCGA	PRHHLGHLL	DEG_APCC_DBOX_1	969:977	Mutation rewiring degron network	0.1111
p.A961T	DO7776	COAD	ICGC	PRHHLGHLL	DEG_APCC_DBOX_1	969:977	Mutation rewiring degron network	0.1111
p.P935H	TCGA-HU-A4H3	STAD	TCGA	ATSSS	DEG_SPOP_SBC_1	942:946	Mutation rewiring degron network	0.1389
p.P935H	DO47903	STAD	ICGC	ATSSS	DEG_SPOP_SBC_1	942:946	Mutation rewiring degron network	0.1389
p.R67H	DO4766	BRCA	ICGC	PRRALRAVY	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.2778
p.P857Q	DO228952	LICA	ICGC	FKIHPE	LIG_APCC_ABBA_1	867:872	Mutation rewiring degron network	0.0556
p.H972N	DO228986	LICA	ICGC	PRHHLGHLL	DEG_APCC_DBOX_1	969:977	Mutation altering degron motif	0.6312
p.A859E	DO229028	LICA	ICGC	FKIHPE	LIG_APCC_ABBA_1	867:872	Mutation rewiring degron network	0.1111
p.G865D	DO229043	LICA	ICGC	FKIHPE	LIG_APCC_ABBA_1	867:872	Mutation rewiring degron network	0.2778
p.T966N	DO229008	LICA	ICGC	PRHHLGHLL	DEG_APCC_DBOX_1	969:977	Mutation rewiring degron network	0.25
p.R67C	DO228371	MALY	ICGC	PRRALRAVY	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.2778
p.G938E	DO222644	MELA	ICGC	ATSSS	DEG_SPOP_SBC_1	942:946	Mutation rewiring degron network	0.2222
p.M941T	DO51532	PACA	ICGC	ATSSS	DEG_SPOP_SBC_1	942:946	Mutation rewiring degron network	0.3056
p.R967W	DO229234	THCA	ICGC	PRHHLGHLL	DEG_APCC_DBOX_1	969:977	Mutation rewiring degron network	0.2778
p.R970G	ACH-000780	Lung Cancer	CCLE	PRHHLGHLL	DEG_APCC_DBOX_1	969:977	Mutation altering degron motif	0.7568
p.A63V	ACH-000890	Lung Cancer	CCLE	PRRALRAVY	DEG_APCC_DBOX_1	57:65	Mutation altering degron motif	0.5825
p.R59M	ACH-001049	Lung Cancer	CCLE	PRRALRAVY	DEG_APCC_DBOX_1	57:65	Mutation altering degron motif	0.7521
p.P55H	ACH-001127	Leukemia	CCLE	PRRALRAVY	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.2778
p.H975Y	ACH-001192	Bone Cancer	CCLE	PRHHLGHLL	DEG_APCC_DBOX_1	969:977	Mutation altering degron motif	0.6118
p.G56R	ACH-001345	Colon/Colorectal Cancer	CCLE	PRRALRAVY	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.3056
p.R58Q	ACH-001484	Leukemia	CCLE	PRRALRAVY	DEG_APCC_DBOX_1	57:65	Mutation altering degron motif	0.7329
p.S65N	ACH-002198	Gastric Cancer	CCLE	PRRALRAVY	DEG_APCC_DBOX_1	57:65	Mutation altering degron motif	0.7069
p.E982D	NCI-H1417	lung	COSMIC	PRHHLGHLL	DEG_APCC_DBOX_1	969:977	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAP3K15

UniProt ID: Q6ZN16

Entrez ID: 389840

Protein name: Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 3) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAP3K15 in