DegronMD

Uniprot ID: Q6ZN16

Source protein: Mitogen-activated protein kinase kinase kinase 15

Source gene: MAP3K15

Class: DEG_APCC_DBOX_1

Location: 57:65

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9743

ASA_SCORE: 60.5333

COIL: 0.4694

CONS_SCORE: 0.4188

DSS_SCORE: 0.5593

HELIX: 0.0098

FCONS_SCORE: 1.4643

RIG_SCORE: 0.7333

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R67H	DO4766	BRCA	ICGC	PRRALRAVY	DEG_APCC_DBOX_1	0.2778
p.R67C	DO228371	MALY	ICGC	PRRALRAVY	DEG_APCC_DBOX_1	0.2778
p.A63V	ACH-000890	Lung Cancer	CCLE	PRRALRAVY	DEG_APCC_DBOX_1	0.5825
p.R59M	ACH-001049	Lung Cancer	CCLE	PRRALRAVY	DEG_APCC_DBOX_1	0.7521
p.P55H	ACH-001127	Leukemia	CCLE	PRRALRAVY	DEG_APCC_DBOX_1	0.2778
p.G56R	ACH-001345	Colon/Colorectal Cancer	CCLE	PRRALRAVY	DEG_APCC_DBOX_1	0.3056
p.R58Q	ACH-001484	Leukemia	CCLE	PRRALRAVY	DEG_APCC_DBOX_1	0.7329
p.S65N	ACH-002198	Gastric Cancer	CCLE	PRRALRAVY	DEG_APCC_DBOX_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZN16	Mitogen-activated protein kinase kinase kinase 15	DEG_APCC_DBOX_1	57:65	PRRALRAVY	APC,CDC20,FZR1	0.9743	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons