DegronMD

Uniprot ID: Q6ZN16

Source protein: Mitogen-activated protein kinase kinase kinase 15

Source gene: MAP3K15

Class: DEG_APCC_DBOX_1

Location: 969:977

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.904

ASA_SCORE: 96.3556

COIL: 0.7484

CONS_SCORE: 0.3763

DSS_SCORE: 0.5636

HELIX: 0.218

FCONS_SCORE: 1.0804

RIG_SCORE: 0.6527

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R967L	TCGA-AJ-A3EL	UCEC	TCGA	PRHHLGHLL	DEG_APCC_DBOX_1	0.2778
p.R967L	DO41542	UCEC	ICGC	PRHHLGHLL	DEG_APCC_DBOX_1	0.2778
p.P980T	TCGA-AX-A2HC	UCEC	TCGA	PRHHLGHLL	DEG_APCC_DBOX_1	0.25
p.P980T	DO41572	UCEC	ICGC	PRHHLGHLL	DEG_APCC_DBOX_1	0.25
p.E982K	TCGA-CD-5804	STAD	TCGA	PRHHLGHLL	DEG_APCC_DBOX_1	0.1944
p.E982K	DO38583	STAD	ICGC	PRHHLGHLL	DEG_APCC_DBOX_1	0.1944
p.A961T	TCGA-D5-6928	COAD	TCGA	PRHHLGHLL	DEG_APCC_DBOX_1	0.1111
p.A961T	DO7776	COAD	ICGC	PRHHLGHLL	DEG_APCC_DBOX_1	0.1111
p.H972N	DO228986	LICA	ICGC	PRHHLGHLL	DEG_APCC_DBOX_1	0.6312
p.T966N	DO229008	LICA	ICGC	PRHHLGHLL	DEG_APCC_DBOX_1	0.25
p.R967W	DO229234	THCA	ICGC	PRHHLGHLL	DEG_APCC_DBOX_1	0.2778
p.R970G	ACH-000780	Lung Cancer	CCLE	PRHHLGHLL	DEG_APCC_DBOX_1	0.7568
p.H975Y	ACH-001192	Bone Cancer	CCLE	PRHHLGHLL	DEG_APCC_DBOX_1	0.6118
p.E982D	NCI-H1417	lung	COSMIC	PRHHLGHLL	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZN16	Mitogen-activated protein kinase kinase kinase 15	DEG_APCC_DBOX_1	969:977	PRHHLGHLL	APC,CDC20,FZR1	0.904	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons