DegronMD

Uniprot ID: Q6ZN16

Source protein: Mitogen-activated protein kinase kinase kinase 15

Source gene: MAP3K15

Class: LIG_APCC_ABBA_1

Location: 867:872

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8098

ASA_SCORE: 85.5667

COIL: 0.9648

CONS_SCORE: 0.5654

DSS_SCORE: 0.195

HELIX: 0.023

FCONS_SCORE: 1.0471

RIG_SCORE: 0.804

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F862L	TCGA-06-5416	GBM	TCGA	FKIHPE	LIG_APCC_ABBA_1	0.1944
p.F862L	DO10880	GBM	ICGC	FKIHPE	LIG_APCC_ABBA_1	0.1944
p.R882Q	TCGA-44-7670	LUAD	TCGA	FKIHPE	LIG_APCC_ABBA_1	0.0556
p.R882Q	DO23555	LUAD	ICGC	FKIHPE	LIG_APCC_ABBA_1	0.0556
p.Q858H	TCGA-A5-A1OF	UCEC	TCGA	FKIHPE	LIG_APCC_ABBA_1	0.0833
p.Q858H	DO42568	UCEC	ICGC	FKIHPE	LIG_APCC_ABBA_1	0.0833
p.P857L	TCGA-A5-A1OF	UCEC	TCGA	FKIHPE	LIG_APCC_ABBA_1	0.0556
p.P857L	DO42568	UCEC	ICGC	FKIHPE	LIG_APCC_ABBA_1	0.0556
p.V864L	TCGA-AJ-A3EL	UCEC	TCGA	FKIHPE	LIG_APCC_ABBA_1	0.25
p.P857Q	DO228952	LICA	ICGC	FKIHPE	LIG_APCC_ABBA_1	0.0556
p.A859E	DO229028	LICA	ICGC	FKIHPE	LIG_APCC_ABBA_1	0.1111
p.G865D	DO229043	LICA	ICGC	FKIHPE	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZN16	Mitogen-activated protein kinase kinase kinase 15	LIG_APCC_ABBA_1	867:872	FKIHPE	APC,CDC20,FZR1	0.8098	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons