DegronMD - Q9UHL9(GTF2IRD1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R921W	TCGA-A5-A0VP	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	911:915	Mutation rewiring degron network	0.1667
p.R921W	DO42600	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	911:915	Mutation rewiring degron network	0.1667
p.R921W	SIDM01090	Colorectal Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	911:915	Mutation rewiring degron network	0.1667
p.R921W	RKO	large intestine	COSMIC	VSSSS	DEG_SPOP_SBC_1	911:915	Mutation rewiring degron network	0.1667
p.A905V	TCGA-AA-3864	COAD	TCGA	VSSSS	DEG_SPOP_SBC_1	911:915	Mutation rewiring degron network	0.1667
p.G70E	TCGA-BR-8060	STAD	TCGA	VAVHDE	LIG_APCC_ABBA_1	55:60	Mutation rewiring degron network	0.0556
p.G70E	DO38205	STAD	ICGC	VAVHDE	LIG_APCC_ABBA_1	55:60	Mutation rewiring degron network	0.0556
p.E60D	TCGA-E1-A7YE	LGG	TCGA	VAVHDE	LIG_APCC_ABBA_1	55:60	Mutation altering degron motif	0.5647
p.E60D	DO223667	LGG	ICGC	VAVHDE	LIG_APCC_ABBA_1	55:60	Mutation altering degron motif	0.5647
p.P256S	TCGA-EB-A85J	SKCM	TCGA	ATSSS	DEG_SPOP_SBC_1	248:252	Mutation rewiring degron network	0.2222
p.P256S	TCGA-YD-A9TA	SKCM	TCGA	ATSSS	DEG_SPOP_SBC_1	248:252	Mutation rewiring degron network	0.2222
p.R917C	TCGA-FI-A2D5	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	911:915	Mutation blocking phosphorylation signal	0.7222
p.R917C	DO41331	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	911:915	Mutation blocking phosphorylation signal	0.7222
p.K47R	DO227817	BRCA	ICGC	VAVHDE	LIG_APCC_ABBA_1	55:60	Mutation substituting flanking lysine	0.2222
p.E68A	DO230315	COCA	ICGC	VAVHDE	LIG_APCC_ABBA_1	55:60	Mutation rewiring degron network	0.1111
p.V52M	DO50381	ESAD	ICGC	VAVHDE	LIG_APCC_ABBA_1	55:60	Mutation rewiring degron network	0.25
p.A62S	DO228976	LICA	ICGC	VAVHDE	LIG_APCC_ABBA_1	55:60	Mutation rewiring degron network	0.2778
p.A53S	DO229006	LICA	ICGC	VAVHDE	LIG_APCC_ABBA_1	55:60	Mutation rewiring degron network	0.2778
p.A50S	DO229009	LICA	ICGC	VAVHDE	LIG_APCC_ABBA_1	55:60	Mutation rewiring degron network	0.1944
p.I914V	DO231778	LINC	ICGC	VSSSS	DEG_SPOP_SBC_1	911:915	Mutation altering degron motif	0.7076
p.K920R	DO229295	LMS	ICGC	VSSSS	DEG_SPOP_SBC_1	911:915	Mutation rewiring degron network	0.1944
p.SE923SK	DO222494	MELA	ICGC	VSSSS	DEG_SPOP_SBC_1	911:915	Mutation rewiring degron network	0
p.G70W	DO34736	PACA	ICGC	VAVHDE	LIG_APCC_ABBA_1	55:60	Mutation rewiring degron network	0.0556
p.D59N	DO227710	PBCA	ICGC	VAVHDE	LIG_APCC_ABBA_1	55:60	Mutation altering degron motif	0.5821
p.S255N	DO43186	UCEC	ICGC	ATSSS	DEG_SPOP_SBC_1	248:252	Mutation rewiring degron network	0.25
p.A248V	DO41644	UCEC	ICGC	ATSSS	DEG_SPOP_SBC_1	248:252	Mutation altering degron motif	0.5825
p.V239M	DO41361	UCEC	ICGC	ATSSS	DEG_SPOP_SBC_1	248:252	Mutation rewiring degron network	0.0833
p.H58R	SIDM00528	Breast Carcinoma	GDSC	VAVHDE	LIG_APCC_ABBA_1	55:60	Mutation altering degron motif	0.8244
p.H58R	ACH-000934	Breast Cancer	CCLE	VAVHDE	LIG_APCC_ABBA_1	55:60	Mutation altering degron motif	0.8244
p.H58R	MDA-MB-361	breast	COSMIC	VAVHDE	LIG_APCC_ABBA_1	55:60	Mutation altering degron motif	0.8244
p.G251S	SIDM01397	Melanoma	GDSC	ATSSS	DEG_SPOP_SBC_1	248:252	Mutation altering degron motif	0.6993
p.V922M	ACH-001421	Eye Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	911:915	Mutation rewiring degron network	0.1389
p.S250F	ACH-001550	Skin Cancer	CCLE	ATSSS	DEG_SPOP_SBC_1	248:252	Mutation altering degron motif	0.7982
p.S250F	MCC13	skin	COSMIC	ATSSS	DEG_SPOP_SBC_1	248:252	Mutation altering degron motif	0.7982
p.R904W	RKO	large intestine	COSMIC	VSSSS	DEG_SPOP_SBC_1	911:915	Mutation rewiring degron network	0.1389

Kaplan plot for GTF2IRD1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GTF2IRD1

UniProt ID: Q9UHL9

Entrez ID: 9569

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GTF2IRD1 in