DegronMD

Uniprot ID: Q9UHL9

Source protein: General transcription factor II-I repeat domain-containing protein 1

Source gene: GTF2IRD1

Class: LIG_APCC_ABBA_1

Location: 55:60

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.556

ASA_SCORE: 51.2833

COIL: 0.395

CONS_SCORE: 0.798

DSS_SCORE: 0.0649

HELIX: 0.0225

FCONS_SCORE: 0.8831

RIG_SCORE: 0.8521

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G70E	TCGA-BR-8060	STAD	TCGA	VAVHDE	LIG_APCC_ABBA_1	0.0556
p.G70E	DO38205	STAD	ICGC	VAVHDE	LIG_APCC_ABBA_1	0.0556
p.E60D	TCGA-E1-A7YE	LGG	TCGA	VAVHDE	LIG_APCC_ABBA_1	0.5647
p.E60D	DO223667	LGG	ICGC	VAVHDE	LIG_APCC_ABBA_1	0.5647
p.K47R	DO227817	BRCA	ICGC	VAVHDE	LIG_APCC_ABBA_1	0.2222
p.E68A	DO230315	COCA	ICGC	VAVHDE	LIG_APCC_ABBA_1	0.1111
p.V52M	DO50381	ESAD	ICGC	VAVHDE	LIG_APCC_ABBA_1	0.25
p.A62S	DO228976	LICA	ICGC	VAVHDE	LIG_APCC_ABBA_1	0.2778
p.A53S	DO229006	LICA	ICGC	VAVHDE	LIG_APCC_ABBA_1	0.2778
p.A50S	DO229009	LICA	ICGC	VAVHDE	LIG_APCC_ABBA_1	0.1944
p.G70W	DO34736	PACA	ICGC	VAVHDE	LIG_APCC_ABBA_1	0.0556
p.D59N	DO227710	PBCA	ICGC	VAVHDE	LIG_APCC_ABBA_1	0.5821
p.H58R	SIDM00528	Breast Carcinoma	GDSC	VAVHDE	LIG_APCC_ABBA_1	0.8244
p.H58R	ACH-000934	Breast Cancer	CCLE	VAVHDE	LIG_APCC_ABBA_1	0.8244
p.H58R	MDA-MB-361	breast	COSMIC	VAVHDE	LIG_APCC_ABBA_1	0.8244

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UHL9	General transcription factor II-I repeat domain-containing protein 1	LIG_APCC_ABBA_1	55:60	VAVHDE	APC,CDC20,FZR1	0.556	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons