DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SPOP_SBC_1

Location: 4296:4300

E3 ligase: SPOP

DEGRON score: 0.9858

ASA_SCORE: 81.3

COIL: 0.922

CONS_SCORE: 0.2711

DSS_SCORE: 0.6314

HELIX: 0.0188

FCONS_SCORE: 0.9346

RIG_SCORE: 0.5886

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P4309A	TCGA-37-A5EL	LUSC	TCGA	ATSSS	DEG_SPOP_SBC_1	0.0833
p.R4303K	TCGA-EE-A3AG	SKCM	TCGA	ATSSS	DEG_SPOP_SBC_1	0.25
p.R4303K	TCGA-GN-A4U8	SKCM	TCGA	ATSSS	DEG_SPOP_SBC_1	0.25
p.R4303K	TCGA-YG-AA3N	SKCM	TCGA	ATSSS	DEG_SPOP_SBC_1	0.25
p.T4307A	TCGA-FD-A3N6	BLCA	TCGA	ATSSS	DEG_SPOP_SBC_1	0.5833
p.T4307A	SIDM00158	Glioblastoma	GDSC	ATSSS	DEG_SPOP_SBC_1	0.5833
p.T4307N	DO224709	BRCA	ICGC	ATSSS	DEG_SPOP_SBC_1	0.5833
p.A4308V	DO224709	BRCA	ICGC	ATSSS	DEG_SPOP_SBC_1	0.1111
p.R4306K	DO37471	SKCM	ICGC	ATSSS	DEG_SPOP_SBC_1	0.1667
p.R4306K	DO47320	SKCM	ICGC	ATSSS	DEG_SPOP_SBC_1	0.1667
p.R4306K	DO51298	SKCM	ICGC	ATSSS	DEG_SPOP_SBC_1	0.1667
p.S4302F	DO38727	STAD	ICGC	ATSSS	DEG_SPOP_SBC_1	0.2778
p.A4294V	DO38727	STAD	ICGC	ATSSS	DEG_SPOP_SBC_1	0.2778
p.R4303M	SIDM00120	Prostate Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	0.25
p.R4303M	ACH-000979	Prostate Cancer	CCLE	ATSSS	DEG_SPOP_SBC_1	0.25
p.R4303M	DU-145	prostate	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.25
p.A4305V	RPMI-6666	haematopoietic_and_lymphoid_tissue	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.1944
p.A4305V	NCI-H1755	lung	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.1944
p.A4305V	AU565	breast	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.1944
p.A4305V	D-423MG	central_nervous_system	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.1944
p.A4305V	HCC202	breast	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.1944
p.A4305V	HPAC	pancreas	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.1944
p.A4305V	SK-MEL-24	skin	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.1944
p.A4305V	NCI-H2444	lung	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.1944
p.A4305V	EM-2	haematopoietic_and_lymphoid_tissue	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.1944
p.A4305V	T47D	breast	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.1944
p.A4305V	U-118-MG	central_nervous_system	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.1944
p.A4305V	U-87-MG	central_nervous_system	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.1944
p.A4305V	NCI-H1573	lung	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.1944
p.A4305V	BICR78	upper_aerodigestive_tract	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.1944
p.A4305V	H290	pleura	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.1944
p.A4305V	Hs939-T	skin	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.1944
p.A4305V	RPMI-2650	upper_aerodigestive_tract	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.1944
p.T4304N	H290	pleura	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.2222
p.T4304N	T47D	breast	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.2222
p.T4304N	SK-MEL-24	skin	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.2222
p.T4304N	D-423MG	central_nervous_system	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.2222
p.T4304N	RPMI-6666	haematopoietic_and_lymphoid_tissue	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.2222
p.T4304N	U-87-MG	central_nervous_system	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.2222
p.T4304N	NCI-H2444	lung	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.2222
p.T4304N	AU565	breast	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.2222
p.T4304N	RPMI-2650	upper_aerodigestive_tract	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.2222
p.T4304N	HCC202	breast	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.2222
p.T4304N	Hs939-T	skin	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.2222
p.T4304N	EM-2	haematopoietic_and_lymphoid_tissue	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.2222
p.T4304N	U-118-MG	central_nervous_system	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.2222
p.T4304N	HPAC	pancreas	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.2222
p.T4304N	NCI-H1573	lung	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7KAX9	Rho GTPase-activating protein 32	DEG_SPOP_SBC_1	1434:1438	ATSSS	SPOP	0.9982	More...
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	887:891	ATSSS	SPOP	0.9464	More...
O15372	Eukaryotic translation initiation factor 3 subunit H	DEG_SPOP_SBC_1	12:16	ATSSS	SPOP	0.9947	More...
O15481	Melanoma-associated antigen B4	DEG_SPOP_SBC_1	337:341	ATSSS	SPOP	0.9724	More...
O75486	Transcription initiation protein SPT3 homolog	DEG_SPOP_SBC_1	12:16	ATSSS	SPOP	0.9822	More...
P05155	Plasma protease C1 inhibitor	DEG_SPOP_SBC_1	26:30	ATSSS	SPOP	0.9771	More...
P13807	Glycogen [starch] synthase, muscle	DEG_SPOP_SBC_1	714:718	ATSSS	SPOP	0.9984	More...
P20020	Plasma membrane calcium-transporting ATPase 1	DEG_SPOP_SBC_1	1204:1208	ATSSS	SPOP	0.9992	More...
P42566	Epidermal growth factor receptor substrate 15	DEG_SPOP_SBC_1	742:746	ATSSS	SPOP	0.9945	More...
P46100	Transcriptional regulator ATRX	DEG_SPOP_SBC_1	1988:1992	ATSSS	SPOP	0.9482	More...
P51788	Chloride channel protein 2	DEG_SPOP_SBC_1	861:865	ATSSS	SPOP	0.98	More...
Q01814	Plasma membrane calcium-transporting ATPase 2	DEG_SPOP_SBC_1	1227:1231	ATSSS	SPOP	0.999	More...
Q03252	Lamin-B2	DEG_SPOP_SBC_1	417:421	ATSSS	SPOP	0.9957	More...
Q14004	Cyclin-dependent kinase 13	DEG_SPOP_SBC_1	263:267	ATSSS	SPOP	0.9936	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	666:670	ATSSS	SPOP	0.9384	More...
Q6VY07	Phosphofurin acidic cluster sorting protein 1	DEG_SPOP_SBC_1	53:57	ATSSS	SPOP	0.9856	More...
Q6ZN16	Mitogen-activated protein kinase kinase kinase 15	DEG_SPOP_SBC_1	942:946	ATSSS	SPOP	0.807	More...
Q86VM9	Zinc finger CCCH domain-containing protein 18	DEG_SPOP_SBC_1	716:720	ATSSS	SPOP	0.776	More...
Q86XP3	ATP-dependent RNA helicase DDX42	DEG_SPOP_SBC_1	41:45	ATSSS	SPOP	0.9905	More...
Q8IV53	DENN domain-containing protein 1C	DEG_SPOP_SBC_1	631:635	ATSSS	SPOP	0.9832	More...
Q8IZF2	Adhesion G protein-coupled receptor F5	DEG_SPOP_SBC_1	1330:1334	ATSSS	SPOP	0.8435	More...
Q8N264	Rho GTPase-activating protein 24	DEG_SPOP_SBC_1	623:627	ATSSS	SPOP	0.9987	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11879:11883	ATSSS	SPOP	0.9996	More...
Q92540	Nonsense-mediated mRNA decay factor SMG7	DEG_SPOP_SBC_1	1063:1067	ATSSS	SPOP	0.9984	More...
Q92859	Neogenin	DEG_SPOP_SBC_1	1330:1334	ATSSS	SPOP	0.9832	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	910:914	ATSSS	SPOP	0.9474	More...
Q96T88	E3 ubiquitin-protein ligase UHRF1	DEG_SPOP_SBC_1	389:393	ATSSS	SPOP	0.5185	More...
Q99250	Sodium channel protein type 2 subunit alpha	DEG_SPOP_SBC_1	1137:1141	ATSSS	SPOP	0.5379	More...
Q99814	Endothelial PAS domain-containing protein 1	DEG_SPOP_SBC_1	472:476	ATSSS	SPOP	0.9851	More...
Q9BTV5	Fibronectin type III and SPRY domain-containing protein 1	DEG_SPOP_SBC_1	487:491	ATSSS	SPOP	0.9287	More...
Q9BX66	Sorbin and SH3 domain-containing protein 1	DEG_SPOP_SBC_1	149:153	ATSSS	SPOP	0.9831	More...
Q9H1B7	Probable E3 ubiquitin-protein ligase IRF2BPL	DEG_SPOP_SBC_1	307:311	ATSSS	SPOP	0.9719	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	976:980	ATSSS	SPOP	0.798	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3039:3043	ATSSS	SPOP	0.9921	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4296:4300	ATSSS	SPOP	0.9858	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4723:4727	ATSSS	SPOP	0.9213	More...
Q9NPF0	CD320 antigen	DEG_SPOP_SBC_1	214:218	ATSSS	SPOP	0.9034	More...
Q9NY46	Sodium channel protein type 3 subunit alpha	DEG_SPOP_SBC_1	1135:1139	ATSSS	SPOP	0.9733	More...
Q9UHL9	General transcription factor II-I repeat domain-containing protein 1	DEG_SPOP_SBC_1	248:252	ATSSS	SPOP	0.8868	More...
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	DEG_SPOP_SBC_1	463:467	ATSSS	SPOP	0.9992	More...
Q9UPS6	Histone-lysine N-methyltransferase SETD1B	DEG_SPOP_SBC_1	1152:1156	ATSSS	SPOP	0.9555	More...
A0PJX4	Protein shisa-3 homolog	DEG_SPOP_SBC_1	165:169	ATSSS	SPOP	0.8425	More...
Q9UL36	Zinc finger protein 236	DEG_SPOP_SBC_1	1514:1518	ATSSS	SPOP	0.92	More...
D6RIA3	Uncharacterized protein C4orf54	DEG_SPOP_SBC_1	297:301	ATSSS	SPOP	0.9982	More...
Q5BKX6	Solute carrier family 45 member 4	DEG_SPOP_SBC_1	407:411	ATSSS	SPOP	0.9945	More...
Q6ZMN7	PDZ domain-containing RING finger protein 4	DEG_SPOP_SBC_1	542:546	ATSSS	SPOP	0.764	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	494:498	ATSSS	SPOP	0.9812	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ATSSS

Degron related mutations and impact score

Drug responses associated with MUC5B mutations

All proteins holding degron of ATSSS