DegronMD - Q8N264(ARHGAP24)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S615I	TCGA-A5-A0G1	UCEC	TCGA	ATSSS	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.1111
p.S615I	DO42472	UCEC	ICGC	ATSSS	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.1111
p.R619Q	TCGA-A6-3809	COAD	TCGA	ATSSS	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.2222
p.R619Q	DO8722	COAD	ICGC	ATSSS	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.2222
p.S620I	TCGA-AJ-A3EK	UCEC	TCGA	ATSSS	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.25
p.S620I	DO41584	UCEC	ICGC	ATSSS	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.25
p.A353T	TCGA-AJ-A3EL	UCEC	TCGA	NKENN	DEG_APCC_KENBOX_2	360:364	Mutation rewiring degron network	0.1389
p.A353T	DO41542	UCEC	ICGC	NKENN	DEG_APCC_KENBOX_2	360:364	Mutation rewiring degron network	0.1389
p.K351N	TCGA-AX-A05Z	UCEC	TCGA	NKENN	DEG_APCC_KENBOX_2	360:364	Mutation substituting flanking lysine	0.1944
p.K351N	DO40884	UCEC	ICGC	NKENN	DEG_APCC_KENBOX_2	360:364	Mutation substituting flanking lysine	0.1944
p.K352E	TCGA-BR-7703	STAD	TCGA	NKENN	DEG_APCC_KENBOX_2	360:364	Mutation substituting flanking lysine	0.2222
p.K352E	DO38232	STAD	ICGC	NKENN	DEG_APCC_KENBOX_2	360:364	Mutation substituting flanking lysine	0.2222
p.S637N	DO234230	ESAD	ICGC	ATSSS	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.0556
p.R622H	DO229505	LAML	ICGC	ATSSS	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.3056
p.R622H	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.3056
p.P370L	SIDM00955	Melanoma	GDSC	NKENN	DEG_APCC_KENBOX_2	360:364	Mutation rewiring degron network	0.1667
p.P370L	ACH-000812	Skin Cancer	CCLE	NKENN	DEG_APCC_KENBOX_2	360:364	Mutation rewiring degron network	0.1667
p.P370L	COLO-783	skin	COSMIC	NKENN	DEG_APCC_KENBOX_2	360:364	Mutation rewiring degron network	0.1667
p.G356W	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	NKENN	DEG_APCC_KENBOX_2	360:364	Mutation rewiring degron network	0.2222
p.G356W	ACH-000893	Lung Cancer	CCLE	NKENN	DEG_APCC_KENBOX_2	360:364	Mutation rewiring degron network	0.2222
p.G356W	NCI-H1651	lung	COSMIC	NKENN	DEG_APCC_KENBOX_2	360:364	Mutation rewiring degron network	0.2222
p.S371G	SIDM00487	Colorectal Carcinoma	GDSC	NKENN	DEG_APCC_KENBOX_2	360:364	Mutation blocking phosphorylation signal	0.5833
p.S371G	ACH-000963	Colon/Colorectal Cancer	CCLE	NKENN	DEG_APCC_KENBOX_2	360:364	Mutation blocking phosphorylation signal	0.5833
p.S371G	CCK-81	large intestine	COSMIC	NKENN	DEG_APCC_KENBOX_2	360:364	Mutation blocking phosphorylation signal	0.5833
p.R367K	JVM-2	haematopoietic and lymphoid tissue	COSMIC	NKENN	DEG_APCC_KENBOX_2	360:364	Mutation substituting flanking lysine	0.3611
p.R365K	JVM-2	haematopoietic and lymphoid tissue	COSMIC	NKENN	DEG_APCC_KENBOX_2	360:364	Mutation rewiring degron network	0.3056
p.E628Q	TUR	haematopoietic and lymphoid tissue	COSMIC	ATSSS	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.3056
p.E626Q	TUR	haematopoietic and lymphoid tissue	COSMIC	ATSSS	DEG_SPOP_SBC_1	623:627	Mutation altering degron motif	0.6744

Kaplan plot for ARHGAP24 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARHGAP24

UniProt ID: Q8N264

Entrez ID: 83478

Protein name: Rho GTPase-activating protein 24 (Filamin-A-associated RhoGAP) (FilGAP) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa) (RC-GAP72) (Rho-type GTPase-activating protein 24) (RhoGAP of 73 kDa) (Sarcoma antigen NY-SAR-88) (p73RhoGAP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARHGAP24 in