DegronMD

Uniprot ID: Q8N264

Source protein: Rho GTPase-activating protein 24

Source gene: ARHGAP24

Class: DEG_APCC_KENBOX_2

Location: 360:364

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7955

ASA_SCORE: 111.84

COIL: 0.7494

CONS_SCORE: 0.201

DSS_SCORE: 0.7656

HELIX: 0.2382

FCONS_SCORE: 0.837

RIG_SCORE: 0.6211

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A353T	TCGA-AJ-A3EL	UCEC	TCGA	NKENN	DEG_APCC_KENBOX_2	0.1389
p.A353T	DO41542	UCEC	ICGC	NKENN	DEG_APCC_KENBOX_2	0.1389
p.K351N	TCGA-AX-A05Z	UCEC	TCGA	NKENN	DEG_APCC_KENBOX_2	0.1944
p.K351N	DO40884	UCEC	ICGC	NKENN	DEG_APCC_KENBOX_2	0.1944
p.K352E	TCGA-BR-7703	STAD	TCGA	NKENN	DEG_APCC_KENBOX_2	0.2222
p.K352E	DO38232	STAD	ICGC	NKENN	DEG_APCC_KENBOX_2	0.2222
p.P370L	SIDM00955	Melanoma	GDSC	NKENN	DEG_APCC_KENBOX_2	0.1667
p.P370L	ACH-000812	Skin Cancer	CCLE	NKENN	DEG_APCC_KENBOX_2	0.1667
p.P370L	COLO-783	skin	COSMIC	NKENN	DEG_APCC_KENBOX_2	0.1667
p.G356W	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	NKENN	DEG_APCC_KENBOX_2	0.2222
p.G356W	ACH-000893	Lung Cancer	CCLE	NKENN	DEG_APCC_KENBOX_2	0.2222
p.G356W	NCI-H1651	lung	COSMIC	NKENN	DEG_APCC_KENBOX_2	0.2222
p.S371G	SIDM00487	Colorectal Carcinoma	GDSC	NKENN	DEG_APCC_KENBOX_2	0.5833
p.S371G	ACH-000963	Colon/Colorectal Cancer	CCLE	NKENN	DEG_APCC_KENBOX_2	0.5833
p.S371G	CCK-81	large_intestine	COSMIC	NKENN	DEG_APCC_KENBOX_2	0.5833
p.R367K	JVM-2	haematopoietic_and_lymphoid_tissue	COSMIC	NKENN	DEG_APCC_KENBOX_2	0.3611
p.R365K	JVM-2	haematopoietic_and_lymphoid_tissue	COSMIC	NKENN	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N264	Rho GTPase-activating protein 24	DEG_APCC_KENBOX_2	360:364	NKENN	APC,CDC20,FZR1	0.7955	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons