DegronMD - Q01814(ATP2B2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1211I	TCGA-70-6722	LUSC	TCGA	DSGINLT	DEG_SCF_TRCP1_1	1214:1220	Mutation blocking phosphorylation signal	0.6944
p.T1241M	TCGA-B5-A3FA	UCEC	TCGA	ATSSS	DEG_SPOP_SBC_1	1227:1231	Mutation blocking phosphorylation signal	0.5
p.T1241M	DO52402	UCEC	ICGC	ATSSS	DEG_SPOP_SBC_1	1227:1231	Mutation blocking phosphorylation signal	0.5
p.T1220M	TCGA-BH-A203	BRCA	TCGA	DSGINLT	DEG_SCF_TRCP1_1	1214:1220	Mutation altering degron motif	0.7423
p.T1220M	SIDM00948	Burkitt's Lymphoma	GDSC	DSGINLT	DEG_SCF_TRCP1_1	1214:1220	Mutation altering degron motif	0.7423
p.T1220M	DG-75	haematopoietic and lymphoid tissue	COSMIC	DSGINLT	DEG_SCF_TRCP1_1	1214:1220	Mutation altering degron motif	0.7423
p.T1221I	TCGA-CD-A4MG	STAD	TCGA	DSGINLT	DEG_SCF_TRCP1_1	1214:1220	Mutation rewiring degron network	0.3056
p.T1221I	TCGA-CD-A4MG	STAD	TCGA	ATSSS	DEG_SPOP_SBC_1	1227:1231	Mutation rewiring degron network	0.1667
p.D1214N	TCGA-D1-A17H	UCEC	TCGA	DSGINLT	DEG_SCF_TRCP1_1	1214:1220	Mutation altering degron motif	0.6932
p.D1214N	TCGA-EE-A3AC	SKCM	TCGA	DSGINLT	DEG_SCF_TRCP1_1	1214:1220	Mutation altering degron motif	0.6932
p.D1214N	SIDM00150	Colorectal Carcinoma	GDSC	DSGINLT	DEG_SCF_TRCP1_1	1214:1220	Mutation altering degron motif	0.6932
p.D1214N	KM12	large intestine	COSMIC	DSGINLT	DEG_SCF_TRCP1_1	1214:1220	Mutation altering degron motif	0.6932
p.L1219M	TCGA-FS-A1ZP	SKCM	TCGA	DSGINLT	DEG_SCF_TRCP1_1	1214:1220	Mutation altering degron motif	0.5999
p.S1211C	TCGA-L9-A743	LUAD	TCGA	DSGINLT	DEG_SCF_TRCP1_1	1214:1220	Mutation blocking phosphorylation signal	0.6944
p.S1211C	DO49874	LUAD	ICGC	DSGINLT	DEG_SCF_TRCP1_1	1214:1220	Mutation blocking phosphorylation signal	0.6944
p.T1206M	DO2156	BRCA	ICGC	DSGINLT	DEG_SCF_TRCP1_1	1214:1220	Mutation rewiring degron network	0.1111
p.L1205M	DO37703	SKCM	ICGC	DSGINLT	DEG_SCF_TRCP1_1	1214:1220	Mutation rewiring degron network	0.0833
p.T1207I	DO48009	STAD	ICGC	DSGINLT	DEG_SCF_TRCP1_1	1214:1220	Mutation rewiring degron network	0.1389
p.H1237N	SIDM00753	Squamous Cell Lung Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	1227:1231	Mutation rewiring degron network	0.1667
p.H1237N	NCI-H2023	lung	COSMIC	ATSSS	DEG_SPOP_SBC_1	1227:1231	Mutation rewiring degron network	0.1667
p.N1207S	SIDM01045	Endometrial Carcinoma	GDSC	DSGINLT	DEG_SCF_TRCP1_1	1214:1220	Mutation rewiring degron network	0.1389
p.N1207S	EN	endometrium	COSMIC	DSGINLT	DEG_SCF_TRCP1_1	1214:1220	Mutation rewiring degron network	0.1389
p.H1206N	NCI-H2023	lung	COSMIC	DSGINLT	DEG_SCF_TRCP1_1	1214:1220	Mutation rewiring degron network	0.1111

Kaplan plot for ATP2B2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ATP2B2

UniProt ID: Q01814

Entrez ID: 491

Protein name: Plasma membrane calcium-transporting ATPase 2 (PMCA2) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 2) (Plasma membrane calcium pump isoform 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ATP2B2 in