DegronMD

Uniprot ID: Q01814

Source protein: Plasma membrane calcium-transporting ATPase 2

Source gene: ATP2B2

Class: DEG_SCF_TRCP1_1

Location: 1214:1220

E3 ligase: BTRC

DEGRON score: 0.9989

ASA_SCORE: 63.9571

COIL: 0.831

CONS_SCORE: 0.2186

DSS_SCORE: 0.5329

HELIX: 0.0713

FCONS_SCORE: 1.0284

RIG_SCORE: 0.6599

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1211I	TCGA-70-6722	LUSC	TCGA	DSGINLT	DEG_SCF_TRCP1_1	0.6944
p.T1220M	TCGA-BH-A203	BRCA	TCGA	DSGINLT	DEG_SCF_TRCP1_1	0.7423
p.T1220M	SIDM00948	Burkitt's Lymphoma	GDSC	DSGINLT	DEG_SCF_TRCP1_1	0.7423
p.T1220M	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	DSGINLT	DEG_SCF_TRCP1_1	0.7423
p.T1221I	TCGA-CD-A4MG	STAD	TCGA	DSGINLT	DEG_SCF_TRCP1_1	0.3056
p.D1214N	TCGA-D1-A17H	UCEC	TCGA	DSGINLT	DEG_SCF_TRCP1_1	0.6932
p.D1214N	TCGA-EE-A3AC	SKCM	TCGA	DSGINLT	DEG_SCF_TRCP1_1	0.6932
p.D1214N	SIDM00150	Colorectal Carcinoma	GDSC	DSGINLT	DEG_SCF_TRCP1_1	0.6932
p.D1214N	KM12	large_intestine	COSMIC	DSGINLT	DEG_SCF_TRCP1_1	0.6932
p.L1219M	TCGA-FS-A1ZP	SKCM	TCGA	DSGINLT	DEG_SCF_TRCP1_1	0.5999
p.S1211C	TCGA-L9-A743	LUAD	TCGA	DSGINLT	DEG_SCF_TRCP1_1	0.6944
p.S1211C	DO49874	LUAD	ICGC	DSGINLT	DEG_SCF_TRCP1_1	0.6944
p.T1206M	DO2156	BRCA	ICGC	DSGINLT	DEG_SCF_TRCP1_1	0.1111
p.L1205M	DO37703	SKCM	ICGC	DSGINLT	DEG_SCF_TRCP1_1	0.0833
p.T1207I	DO48009	STAD	ICGC	DSGINLT	DEG_SCF_TRCP1_1	0.1389
p.N1207S	SIDM01045	Endometrial Carcinoma	GDSC	DSGINLT	DEG_SCF_TRCP1_1	0.1389
p.N1207S	EN	endometrium	COSMIC	DSGINLT	DEG_SCF_TRCP1_1	0.1389
p.H1206N	NCI-H2023	lung	COSMIC	DSGINLT	DEG_SCF_TRCP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q01814	Plasma membrane calcium-transporting ATPase 2	DEG_SCF_TRCP1_1	1214:1220	DSGINLT	BTRC	0.9989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons