DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SPOP_SBC_1

Location: 3039:3043

E3 ligase: SPOP

DEGRON score: 0.9921

ASA_SCORE: 84.24

COIL: 0.94

CONS_SCORE: 0.3401

DSS_SCORE: 0.6093

HELIX: 0.0174

FCONS_SCORE: 1.1554

RIG_SCORE: 0.6014

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S3041C	SIDM00523	Small Cell Lung Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	0.8652
p.S3041C	ACH-000698	Lung Cancer	CCLE	ATSSS	DEG_SPOP_SBC_1	0.8652
p.S3041C	DMS-53	lung	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.8652
p.S3030N	DO8447	COAD	ICGC	ATSSS	DEG_SPOP_SBC_1	0.5278
p.R3046M	TCGA-EB-A6QY	SKCM	TCGA	ATSSS	DEG_SPOP_SBC_1	0.25
p.T3035I	TCGA-44-7671	LUAD	TCGA	ATSSS	DEG_SPOP_SBC_1	0.2222
p.A3048T	SIDM01265	Plasma Cell Myeloma	GDSC	ATSSS	DEG_SPOP_SBC_1	0.1944
p.A3048T	SIDM00773	Non-Cancerous	GDSC	ATSSS	DEG_SPOP_SBC_1	0.1944
p.A3048T	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	0.1944
p.A3048T	SIDM00969	Ovarian Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	0.1944
p.A3048T	SIDM00393	Gastric Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	0.1944
p.A3048T	SIDM00694	Other Solid Cancers	GDSC	ATSSS	DEG_SPOP_SBC_1	0.1944
p.A3048T	SIDM00774	Breast Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	0.1944
p.A3048T	SIDM01664	Prostate Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	0.1944
p.T3049P	TCGA-AP-A056	UCEC	TCGA	ATSSS	DEG_SPOP_SBC_1	0.1667
p.R3049M	DO48702	SKCM	ICGC	ATSSS	DEG_SPOP_SBC_1	0.1667
p.T3033P	ACH-000024	Myeloma	CCLE	ATSSS	DEG_SPOP_SBC_1	0.1667
p.T3033P	OPM-2	haematopoietic_and_lymphoid_tissue	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.1667
p.L3051F	SIDM01104	Melanoma	GDSC	ATSSS	DEG_SPOP_SBC_1	0.1111
p.L3051F	ACH-000640	Skin Cancer	CCLE	ATSSS	DEG_SPOP_SBC_1	0.1111
p.L3051F	SK-MEL-31	skin	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.1111
p.P3052S	TCGA-Z2-A8RT	SKCM	TCGA	ATSSS	DEG_SPOP_SBC_1	0.0833
p.T3052P	DO43971	UCEC	ICGC	ATSSS	DEG_SPOP_SBC_1	0.0833
p.A3029T	SIDM00145	T-Lymphoblastic Leukemia	GDSC	ATSSS	DEG_SPOP_SBC_1	0.0556
p.A3029T	ACH-001127	Leukemia	CCLE	ATSSS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 25 of 26 entries

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Drug responses associated with MUC5B mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of ATSSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZF2	Adhesion G protein-coupled receptor F5	DEG_SPOP_SBC_1	1330:1334	ATSSS	SPOP	0.8435	More...
Q86XP3	ATP-dependent RNA helicase DDX42	DEG_SPOP_SBC_1	41:45	ATSSS	SPOP	0.9905	More...
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	DEG_SPOP_SBC_1	463:467	ATSSS	SPOP	0.9992	More...
Q9NPF0	CD320 antigen	DEG_SPOP_SBC_1	214:218	ATSSS	SPOP	0.9034	More...
P51788	Chloride channel protein 2	DEG_SPOP_SBC_1	861:865	ATSSS	SPOP	0.98	More...
Q14004	Cyclin-dependent kinase 13	DEG_SPOP_SBC_1	263:267	ATSSS	SPOP	0.9936	More...
Q8IV53	DENN domain-containing protein 1C	DEG_SPOP_SBC_1	631:635	ATSSS	SPOP	0.9832	More...
Q96T88	E3 ubiquitin-protein ligase UHRF1	DEG_SPOP_SBC_1	389:393	ATSSS	SPOP	0.5185	More...
Q99814	Endothelial PAS domain-containing protein 1	DEG_SPOP_SBC_1	472:476	ATSSS	SPOP	0.9851	More...
P42566	Epidermal growth factor receptor substrate 15	DEG_SPOP_SBC_1	742:746	ATSSS	SPOP	0.9945	More...
O15372	Eukaryotic translation initiation factor 3 subunit H	DEG_SPOP_SBC_1	12:16	ATSSS	SPOP	0.9947	More...
Q9BTV5	Fibronectin type III and SPRY domain-containing protein 1	DEG_SPOP_SBC_1	487:491	ATSSS	SPOP	0.9287	More...
Q9UHL9	General transcription factor II-I repeat domain-containing protein 1	DEG_SPOP_SBC_1	248:252	ATSSS	SPOP	0.8868	More...
P13807	Glycogen [starch] synthase, muscle	DEG_SPOP_SBC_1	714:718	ATSSS	SPOP	0.9984	More...
Q9UPS6	Histone-lysine N-methyltransferase SETD1B	DEG_SPOP_SBC_1	1152:1156	ATSSS	SPOP	0.9555	More...
Q03252	Lamin-B2	DEG_SPOP_SBC_1	417:421	ATSSS	SPOP	0.9957	More...
O15481	Melanoma-associated antigen B4	DEG_SPOP_SBC_1	337:341	ATSSS	SPOP	0.9724	More...
Q6ZN16	Mitogen-activated protein kinase kinase kinase 15	DEG_SPOP_SBC_1	942:946	ATSSS	SPOP	0.807	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11879:11883	ATSSS	SPOP	0.9996	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	666:670	ATSSS	SPOP	0.9384	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3039:3043	ATSSS	SPOP	0.9921	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4296:4300	ATSSS	SPOP	0.9858	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4723:4727	ATSSS	SPOP	0.9213	More...
Q92859	Neogenin	DEG_SPOP_SBC_1	1330:1334	ATSSS	SPOP	0.9832	More...
Q92540	Nonsense-mediated mRNA decay factor SMG7	DEG_SPOP_SBC_1	1063:1067	ATSSS	SPOP	0.9984	More...

Showing 1 to 25 of 47 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ATSSS

Degron related mutations and impact score

Drug responses associated with MUC5B mutations

All proteins holding degron of ATSSS