DegronMD - Q86VM9(ZC3H18)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V710I	TCGA-A5-A0G2	UCEC	TCGA	ATSSS	DEG_SPOP_SBC_1	716:720	Mutation rewiring degron network	0.1667
p.V710I	TCGA-LN-A4A1	ESCA	TCGA	ATSSS	DEG_SPOP_SBC_1	716:720	Mutation rewiring degron network	0.1667
p.V710I	DO41235	UCEC	ICGC	ATSSS	DEG_SPOP_SBC_1	716:720	Mutation rewiring degron network	0.1667
p.A716D	TCGA-AJ-A3EK	UCEC	TCGA	ATSSS	DEG_SPOP_SBC_1	716:720	Mutation altering degron motif	0.7793
p.A716D	DO41584	UCEC	ICGC	ATSSS	DEG_SPOP_SBC_1	716:720	Mutation altering degron motif	0.7793
p.P655S	TCGA-DU-6407	LGG	TCGA	TKTTAPVPEP	DEG_COP1_1	650:659	Mutation altering degron motif	0.5641
p.P655S	TCGA-EE-A2MD	SKCM	TCGA	TKTTAPVPEP	DEG_COP1_1	650:659	Mutation altering degron motif	0.5641
p.P655S	DO22295	LGG	ICGC	TKTTAPVPEP	DEG_COP1_1	650:659	Mutation altering degron motif	0.5641
p.P655S	DO37851	SKCM	ICGC	TKTTAPVPEP	DEG_COP1_1	650:659	Mutation altering degron motif	0.5641
p.R666L	TCGA-EE-A2MS	SKCM	TCGA	TKTTAPVPEP	DEG_COP1_1	650:659	Mutation rewiring degron network	0.1389
p.R666L	TCGA-ER-A19N	SKCM	TCGA	TKTTAPVPEP	DEG_COP1_1	650:659	Mutation rewiring degron network	0.1389
p.R666L	DO37567	SKCM	ICGC	TKTTAPVPEP	DEG_COP1_1	650:659	Mutation rewiring degron network	0.1389
p.R666L	DO37452	SKCM	ICGC	TKTTAPVPEP	DEG_COP1_1	650:659	Mutation rewiring degron network	0.1389
p.D664Y	TCGA-IB-7651	PAAD	TCGA	TKTTAPVPEP	DEG_COP1_1	650:659	Mutation rewiring degron network	0.1944
p.D664Y	DO46657	PAAD	ICGC	TKTTAPVPEP	DEG_COP1_1	650:659	Mutation rewiring degron network	0.1944
p.E729K	TCGA-L5-A4OO	ESCA	TCGA	ATSSS	DEG_SPOP_SBC_1	716:720	Mutation rewiring degron network	0.0833
p.E667K	TCGA-V5-AASX	ESCA	TCGA	TKTTAPVPEP	DEG_COP1_1	650:659	Mutation rewiring degron network	0.1111
p.P659S	DO228844	LICA	ICGC	TKTTAPVPEP	DEG_COP1_1	650:659	Mutation altering degron motif	0.6752
p.S715I	DO229028	LICA	ICGC	ATSSS	DEG_SPOP_SBC_1	716:720	Mutation rewiring degron network	0.3056
p.T650I	DO229275	THCA	ICGC	TKTTAPVPEP	DEG_COP1_1	650:659	Mutation altering degron motif	0.7078
p.P651L	SIDM01293	Colorectal Carcinoma	GDSC	TKTTAPVPEP	DEG_COP1_1	650:659	Mutation altering degron motif	0.7582
p.P666L	SIDM01281	Colorectal Carcinoma	GDSC	TKTTAPVPEP	DEG_COP1_1	650:659	Mutation rewiring degron network	0.1389
p.P649L	SIDM02021	Esophageal Carcinoma	GDSC	TKTTAPVPEP	DEG_COP1_1	650:659	Mutation rewiring degron network	0.3056
p.S660L	SIDM00683	Prostate Carcinoma	GDSC	TKTTAPVPEP	DEG_COP1_1	650:659	Mutation rewiring degron network	0.3056
p.S724F	SIDM01175	Other Sarcomas	GDSC	ATSSS	DEG_SPOP_SBC_1	716:720	Mutation rewiring degron network	0.2222
p.P641L	SIDM00316	Glioblastoma	GDSC	TKTTAPVPEP	DEG_COP1_1	650:659	Mutation rewiring degron network	0.0833
p.P641L	YH-13	central nervous system	COSMIC	TKTTAPVPEP	DEG_COP1_1	650:659	Mutation rewiring degron network	0.0833
p.S709T	ACH-000726	Esophageal Cancer	CCLE	ATSSS	DEG_SPOP_SBC_1	716:720	Mutation rewiring degron network	0.1389
p.E658K	ACH-001819	Breast Cancer	CCLE	TKTTAPVPEP	DEG_COP1_1	650:659	Mutation altering degron motif	0.7022
p.E658K	MFM-223	breast	COSMIC	TKTTAPVPEP	DEG_COP1_1	650:659	Mutation altering degron motif	0.7022

Kaplan plot for ZC3H18 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZC3H18

UniProt ID: Q86VM9

Entrez ID: 124245

Protein name: Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZC3H18 in