DegronMD

Uniprot ID: Q86VM9

Source protein: Zinc finger CCCH domain-containing protein 18

Source gene: ZC3H18

Class: DEG_COP1_1

Location: 650:659

E3 ligase: COP1

DEGRON score: 0.9783

ASA_SCORE: 108.34

COIL: 0.9698

CONS_SCORE: 0.5315

DSS_SCORE: 0.8674

HELIX: 0.0139

FCONS_SCORE: 1.0162

RIG_SCORE: 0.5566

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P655S	TCGA-DU-6407	LGG	TCGA	TKTTAPVPEP	DEG_COP1_1	0.5641
p.P655S	TCGA-EE-A2MD	SKCM	TCGA	TKTTAPVPEP	DEG_COP1_1	0.5641
p.P655S	DO22295	LGG	ICGC	TKTTAPVPEP	DEG_COP1_1	0.5641
p.P655S	DO37851	SKCM	ICGC	TKTTAPVPEP	DEG_COP1_1	0.5641
p.R666L	TCGA-EE-A2MS	SKCM	TCGA	TKTTAPVPEP	DEG_COP1_1	0.1389
p.R666L	TCGA-ER-A19N	SKCM	TCGA	TKTTAPVPEP	DEG_COP1_1	0.1389
p.R666L	DO37567	SKCM	ICGC	TKTTAPVPEP	DEG_COP1_1	0.1389
p.R666L	DO37452	SKCM	ICGC	TKTTAPVPEP	DEG_COP1_1	0.1389
p.D664Y	TCGA-IB-7651	PAAD	TCGA	TKTTAPVPEP	DEG_COP1_1	0.1944
p.D664Y	DO46657	PAAD	ICGC	TKTTAPVPEP	DEG_COP1_1	0.1944
p.E667K	TCGA-V5-AASX	ESCA	TCGA	TKTTAPVPEP	DEG_COP1_1	0.1111
p.P659S	DO228844	LICA	ICGC	TKTTAPVPEP	DEG_COP1_1	0.6752
p.T650I	DO229275	THCA	ICGC	TKTTAPVPEP	DEG_COP1_1	0.7078
p.P651L	SIDM01293	Colorectal Carcinoma	GDSC	TKTTAPVPEP	DEG_COP1_1	0.7582
p.P666L	SIDM01281	Colorectal Carcinoma	GDSC	TKTTAPVPEP	DEG_COP1_1	0.1389
p.P649L	SIDM02021	Esophageal Carcinoma	GDSC	TKTTAPVPEP	DEG_COP1_1	0.3056
p.S660L	SIDM00683	Prostate Carcinoma	GDSC	TKTTAPVPEP	DEG_COP1_1	0.3056
p.P641L	SIDM00316	Glioblastoma	GDSC	TKTTAPVPEP	DEG_COP1_1	0.0833
p.P641L	YH-13	central_nervous_system	COSMIC	TKTTAPVPEP	DEG_COP1_1	0.0833
p.E658K	ACH-001819	Breast Cancer	CCLE	TKTTAPVPEP	DEG_COP1_1	0.7022
p.E658K	MFM-223	breast	COSMIC	TKTTAPVPEP	DEG_COP1_1	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86VM9	Zinc finger CCCH domain-containing protein 18	DEG_COP1_1	650:659	TKTTAPVPEP	COP1	0.9783	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons