DegronMD - Q03252(LMNB2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A427T	TCGA-A5-A0G1	UCEC	TCGA	ATSSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.1667
p.R430C	TCGA-AA-A01P	COAD	TCGA	ATSSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.0833
p.G429W	TCGA-EE-A2MK	SKCM	TCGA	ATSSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.1111
p.V414I	TCGA-FI-A2D0	UCEC	TCGA	ATSSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.25
p.V414I	SIDM00780	Colorectal Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.25
p.V414I	ACH-000967	Colon/Colorectal Cancer	CCLE	ATSSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.25
p.R313C	TCGA-L5-A4OI	ESCA	TCGA	ARMRLESLS	DEG_APCC_DBOX_1	310:318	Mutation altering degron motif	0.719
p.R304H	TCGA-OR-A5JA	ACC	TCGA	ARMRLESLS	DEG_APCC_DBOX_1	310:318	Mutation rewiring degron network	0.1667
p.R304H	SIDM01169	Ovarian Carcinoma	GDSC	ARMRLESLS	DEG_APCC_DBOX_1	310:318	Mutation rewiring degron network	0.1667
p.R304H	TOV-21G	ovary	COSMIC	ARMRLESLS	DEG_APCC_DBOX_1	310:318	Mutation rewiring degron network	0.1667
p.R410C	DO8642	COAD	ICGC	ATSSS	DEG_SPOP_SBC_1	417:421	Mutation blocking phosphorylation signal	0.5833
p.R316W	DO8730	COAD	ICGC	ARMRLESLS	DEG_APCC_DBOX_1	310:318	Mutation altering degron motif	0.8634
p.R316W	DO220913	MELA	ICGC	ARMRLESLS	DEG_APCC_DBOX_1	310:318	Mutation altering degron motif	0.8634
p.R418Q	DO233270	GACA	ICGC	ATSSS	DEG_SPOP_SBC_1	417:421	Mutation altering degron motif	0.7329
p.R418W	DO233840	GACA	ICGC	ATSSS	DEG_SPOP_SBC_1	417:421	Mutation altering degron motif	0.8634
p.S430R	DO229038	LICA	ICGC	ATSSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.0833
p.G412S	DO51407	PRAD	ICGC	ATSSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.1944
p.A310V	DO51407	PRAD	ICGC	ARMRLESLS	DEG_APCC_DBOX_1	310:318	Mutation altering degron motif	0.5825
p.P424L	DO37782	SKCM	ICGC	ATSSS	DEG_SPOP_SBC_1	417:421	Mutation blocking phosphorylation signal	0.6944
p.A321V	DO37911	SKCM	ICGC	ARMRLESLS	DEG_APCC_DBOX_1	310:318	Mutation rewiring degron network	0.25
p.G409W	DO38177	SKCM	ICGC	ATSSS	DEG_SPOP_SBC_1	417:421	Mutation blocking phosphorylation signal	0.5556
p.A407T	DO42472	UCEC	ICGC	ATSSS	DEG_SPOP_SBC_1	417:421	Mutation blocking phosphorylation signal	0.5
p.R304C	SIDM00955	Melanoma	GDSC	ARMRLESLS	DEG_APCC_DBOX_1	310:318	Mutation rewiring degron network	0.1667
p.R304C	COLO-783	skin	COSMIC	ARMRLESLS	DEG_APCC_DBOX_1	310:318	Mutation rewiring degron network	0.1667
p.A300V	SIDM00282	Colorectal Carcinoma	GDSC	ARMRLESLS	DEG_APCC_DBOX_1	310:318	Mutation rewiring degron network	0.0556
p.A300V	ACH-000998	Colon/Colorectal Cancer	CCLE	ARMRLESLS	DEG_APCC_DBOX_1	310:318	Mutation rewiring degron network	0.0556
p.A300V	CW-2	large intestine	COSMIC	ARMRLESLS	DEG_APCC_DBOX_1	310:318	Mutation rewiring degron network	0.0556
p.R411H	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.1667

Kaplan plot for LMNB2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LMNB2

UniProt ID: Q03252

Entrez ID: 84823

Protein name: Lamin-B2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LMNB2 in