DegronMD

Uniprot ID: Q03252

Source protein: Lamin-B2

Source gene: LMNB2

Class: DEG_APCC_DBOX_1

Location: 310:318

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.758

ASA_SCORE: 86.3667

COIL: 0.0203

CONS_SCORE: 0.5203

DSS_SCORE: 0.3763

HELIX: 0.9802

FCONS_SCORE: 1.1012

RIG_SCORE: 0.7553

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R313C	TCGA-L5-A4OI	ESCA	TCGA	ARMRLESLS	DEG_APCC_DBOX_1	0.719
p.R304H	TCGA-OR-A5JA	ACC	TCGA	ARMRLESLS	DEG_APCC_DBOX_1	0.1667
p.R304H	SIDM01169	Ovarian Carcinoma	GDSC	ARMRLESLS	DEG_APCC_DBOX_1	0.1667
p.R304H	TOV-21G	ovary	COSMIC	ARMRLESLS	DEG_APCC_DBOX_1	0.1667
p.R316W	DO8730	COAD	ICGC	ARMRLESLS	DEG_APCC_DBOX_1	0.8634
p.R316W	DO220913	MELA	ICGC	ARMRLESLS	DEG_APCC_DBOX_1	0.8634
p.A310V	DO51407	PRAD	ICGC	ARMRLESLS	DEG_APCC_DBOX_1	0.5825
p.A321V	DO37911	SKCM	ICGC	ARMRLESLS	DEG_APCC_DBOX_1	0.25
p.R304C	SIDM00955	Melanoma	GDSC	ARMRLESLS	DEG_APCC_DBOX_1	0.1667
p.R304C	COLO-783	skin	COSMIC	ARMRLESLS	DEG_APCC_DBOX_1	0.1667
p.A300V	SIDM00282	Colorectal Carcinoma	GDSC	ARMRLESLS	DEG_APCC_DBOX_1	0.0556
p.A300V	ACH-000998	Colon/Colorectal Cancer	CCLE	ARMRLESLS	DEG_APCC_DBOX_1	0.0556
p.A300V	CW-2	large_intestine	COSMIC	ARMRLESLS	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q03252	Lamin-B2	DEG_APCC_DBOX_1	310:318	ARMRLESLS	APC,CDC20,FZR1	0.758	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons