DegronMD - P51800(CLCNKA)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q645H	TCGA-06-1802	GBM	TCGA	LTLFSE	LIG_APCC_ABBA_1	633:638	Mutation rewiring degron network	0.1389
p.G625C	TCGA-2G-AAF8	TGCT	TCGA	LTLFSE	LIG_APCC_ABBA_1	633:638	Mutation rewiring degron network	0.1111
p.N646H	TCGA-BR-8680	STAD	TCGA	LTLFSE	LIG_APCC_ABBA_1	633:638	Mutation rewiring degron network	0.1111
p.Q643H	TCGA-DU-6392	LGG	TCGA	LTLFSE	LIG_APCC_ABBA_1	633:638	Mutation rewiring degron network	0.1944
p.L647F	TCGA-WE-A8ZX	SKCM	TCGA	LTLFSE	LIG_APCC_ABBA_1	633:638	Mutation rewiring degron network	0.0833
p.L647F	SIDM00806	Osteosarcoma	GDSC	LTLFSE	LIG_APCC_ABBA_1	633:638	Mutation rewiring degron network	0.0833
p.L647F	HOS	bone	COSMIC	LTLFSE	LIG_APCC_ABBA_1	633:638	Mutation rewiring degron network	0.0833
p.Q644H	DO12100	GBM	ICGC	LTLFSE	LIG_APCC_ABBA_1	633:638	Mutation rewiring degron network	0.1667
p.W627C	DO16053	HNSC	ICGC	LTLFSE	LIG_APCC_ABBA_1	633:638	Mutation rewiring degron network	0.1667
p.R623W	DO231992	LICA	ICGC	LTLFSE	LIG_APCC_ABBA_1	633:638	Mutation rewiring degron network	0.0556
p.L640M	DO230530	LUSC	ICGC	LTLFSE	LIG_APCC_ABBA_1	633:638	Mutation rewiring degron network	0.2778
p.N645H	DO233550	PRAD	ICGC	LTLFSE	LIG_APCC_ABBA_1	633:638	Mutation rewiring degron network	0.1389
p.N645H	DO47769	STAD	ICGC	LTLFSE	LIG_APCC_ABBA_1	633:638	Mutation rewiring degron network	0.1389
p.L646F	DO51291	SKCM	ICGC	LTLFSE	LIG_APCC_ABBA_1	633:638	Mutation rewiring degron network	0.1111
p.L646F	HOS	bone	COSMIC	LTLFSE	LIG_APCC_ABBA_1	633:638	Mutation rewiring degron network	0.1111
p.A642T	DO38123	SKCM	ICGC	LTLFSE	LIG_APCC_ABBA_1	633:638	Mutation rewiring degron network	0.2222
p.P627R	SIDM00924	Other Solid Cancers	GDSC	LTLFSE	LIG_APCC_ABBA_1	633:638	Mutation rewiring degron network	0.1667
p.P627R	ACH-000867	Lung Cancer	CCLE	LTLFSE	LIG_APCC_ABBA_1	633:638	Mutation rewiring degron network	0.1667
p.P627R	ChaGo-K-1	lung	COSMIC	LTLFSE	LIG_APCC_ABBA_1	633:638	Mutation rewiring degron network	0.1667
p.R624K	SIDM00527	Colorectal Carcinoma	GDSC	LTLFSE	LIG_APCC_ABBA_1	633:638	Mutation rewiring degron network	0.0833
p.R624K	ACH-000935	Colon/Colorectal Cancer	CCLE	LTLFSE	LIG_APCC_ABBA_1	633:638	Mutation rewiring degron network	0.0833
p.R624K	MDST8	large intestine	COSMIC	LTLFSE	LIG_APCC_ABBA_1	633:638	Mutation rewiring degron network	0.0833
p.R623K	MDST8	large intestine	COSMIC	LTLFSE	LIG_APCC_ABBA_1	633:638	Mutation rewiring degron network	0.0556
p.P626R	ChaGo-K-1	lung	COSMIC	LTLFSE	LIG_APCC_ABBA_1	633:638	Mutation rewiring degron network	0.1389
p.E629Q	NCI-H1688	lung	COSMIC	LTLFSE	LIG_APCC_ABBA_1	633:638	Mutation rewiring degron network	0.2222

Kaplan plot for CLCNKA in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CLCNKA

UniProt ID: P51800

Entrez ID: 1187

Protein name: Chloride channel protein ClC-Ka (Chloride channel Ka) (ClC-K1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CLCNKA in