DegronMD

Uniprot ID: P51800

Source protein: Chloride channel protein ClC-Ka

Source gene: CLCNKA

Class: LIG_APCC_ABBA_1

Location: 633:638

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5513

ASA_SCORE: 62.5667

COIL: 0.6982

CONS_SCORE: 0.4324

DSS_SCORE: 0.2133

HELIX: 0.0627

FCONS_SCORE: 0.8647

RIG_SCORE: 0.8591

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q645H	TCGA-06-1802	GBM	TCGA	LTLFSE	LIG_APCC_ABBA_1	0.1389
p.G625C	TCGA-2G-AAF8	TGCT	TCGA	LTLFSE	LIG_APCC_ABBA_1	0.1111
p.N646H	TCGA-BR-8680	STAD	TCGA	LTLFSE	LIG_APCC_ABBA_1	0.1111
p.Q643H	TCGA-DU-6392	LGG	TCGA	LTLFSE	LIG_APCC_ABBA_1	0.1944
p.L647F	TCGA-WE-A8ZX	SKCM	TCGA	LTLFSE	LIG_APCC_ABBA_1	0.0833
p.L647F	SIDM00806	Osteosarcoma	GDSC	LTLFSE	LIG_APCC_ABBA_1	0.0833
p.L647F	HOS	bone	COSMIC	LTLFSE	LIG_APCC_ABBA_1	0.0833
p.Q644H	DO12100	GBM	ICGC	LTLFSE	LIG_APCC_ABBA_1	0.1667
p.W627C	DO16053	HNSC	ICGC	LTLFSE	LIG_APCC_ABBA_1	0.1667
p.R623W	DO231992	LICA	ICGC	LTLFSE	LIG_APCC_ABBA_1	0.0556
p.L640M	DO230530	LUSC	ICGC	LTLFSE	LIG_APCC_ABBA_1	0.2778
p.N645H	DO233550	PRAD	ICGC	LTLFSE	LIG_APCC_ABBA_1	0.1389
p.N645H	DO47769	STAD	ICGC	LTLFSE	LIG_APCC_ABBA_1	0.1389
p.L646F	DO51291	SKCM	ICGC	LTLFSE	LIG_APCC_ABBA_1	0.1111
p.L646F	HOS	bone	COSMIC	LTLFSE	LIG_APCC_ABBA_1	0.1111
p.A642T	DO38123	SKCM	ICGC	LTLFSE	LIG_APCC_ABBA_1	0.2222
p.P627R	SIDM00924	Other Solid Cancers	GDSC	LTLFSE	LIG_APCC_ABBA_1	0.1667
p.P627R	ACH-000867	Lung Cancer	CCLE	LTLFSE	LIG_APCC_ABBA_1	0.1667
p.P627R	ChaGo-K-1	lung	COSMIC	LTLFSE	LIG_APCC_ABBA_1	0.1667
p.R624K	SIDM00527	Colorectal Carcinoma	GDSC	LTLFSE	LIG_APCC_ABBA_1	0.0833
p.R624K	ACH-000935	Colon/Colorectal Cancer	CCLE	LTLFSE	LIG_APCC_ABBA_1	0.0833
p.R624K	MDST8	large_intestine	COSMIC	LTLFSE	LIG_APCC_ABBA_1	0.0833
p.R623K	MDST8	large_intestine	COSMIC	LTLFSE	LIG_APCC_ABBA_1	0.0556
p.P626R	ChaGo-K-1	lung	COSMIC	LTLFSE	LIG_APCC_ABBA_1	0.1389
p.E629Q	NCI-H1688	lung	COSMIC	LTLFSE	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51800	Chloride channel protein ClC-Ka	LIG_APCC_ABBA_1	633:638	LTLFSE	APC,CDC20,FZR1	0.5513	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons