DegronMD - P51970(NDUFA8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D108V	TCGA-77-7140	LUSC	TCGA	VRPDLGELS	DEG_APCC_DBOX_1	118:126	Mutation rewiring degron network	0.0556
p.D108V	DO26455	LUSC	ICGC	VRPDLGELS	DEG_APCC_DBOX_1	118:126	Mutation rewiring degron network	0.0556
p.K130T	TCGA-AP-A1DV	UCEC	TCGA	VRPDLGELS	DEG_APCC_DBOX_1	118:126	Mutation substituting flanking lysine	0.3333
p.K130T	DO43186	UCEC	ICGC	VRPDLGELS	DEG_APCC_DBOX_1	118:126	Mutation substituting flanking lysine	0.3333
p.S126A	TCGA-B5-A3FA	UCEC	TCGA	VRPDLGELS	DEG_APCC_DBOX_1	118:126	Mutation altering degron motif	0.6477
p.S126A	DO52402	UCEC	ICGC	VRPDLGELS	DEG_APCC_DBOX_1	118:126	Mutation altering degron motif	0.6477
p.R119W	TCGA-D3-A8GL	SKCM	TCGA	VRPDLGELS	DEG_APCC_DBOX_1	118:126	Mutation altering degron motif	0.8634
p.R119W	DO50287	SKCM	ICGC	VRPDLGELS	DEG_APCC_DBOX_1	118:126	Mutation altering degron motif	0.8634
p.P136T	DO229037	LICA	ICGC	VRPDLGELS	DEG_APCC_DBOX_1	118:126	Mutation rewiring degron network	0.0556
p.P136T	DO229045	LICA	ICGC	VRPDLGELS	DEG_APCC_DBOX_1	118:126	Mutation rewiring degron network	0.0556
p.D121G	DO229268	THCA	ICGC	VRPDLGELS	DEG_APCC_DBOX_1	118:126	Mutation altering degron motif	0.6087
p.D121E	DO229221	THCA	ICGC	VRPDLGELS	DEG_APCC_DBOX_1	118:126	Mutation altering degron motif	0.5647
p.E109K	SIDM01016	T-Lymphoblastic Leukemia	GDSC	VRPDLGELS	DEG_APCC_DBOX_1	118:126	Mutation rewiring degron network	0.0833
p.E109K	ACH-000995	Leukemia	CCLE	VRPDLGELS	DEG_APCC_DBOX_1	118:126	Mutation rewiring degron network	0.0833
p.E109K	Jurkat	haematopoietic and lymphoid tissue	COSMIC	VRPDLGELS	DEG_APCC_DBOX_1	118:126	Mutation rewiring degron network	0.0833
p.R135Q	SIDM01689	B-Lymphoblastic Leukemia	GDSC	VRPDLGELS	DEG_APCC_DBOX_1	118:126	Mutation rewiring degron network	0.0833

Kaplan plot for NDUFA8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NDUFA8

UniProt ID: P51970

Entrez ID: 4702

Protein name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (Complex I-19kD) (CI-19kD) (Complex I-PGIV) (CI-PGIV) (NADH-ubiquinone oxidoreductase 19 kDa subunit)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NDUFA8 in