DegronMD

Uniprot ID: P51970

Source protein: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

Source gene: NDUFA8

Class: DEG_APCC_DBOX_1

Location: 118:126

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8653

ASA_SCORE: 66.5333

COIL: 0.7776

CONS_SCORE: 0.4393

DSS_SCORE: 0.2715

HELIX: 0.0864

FCONS_SCORE: 0.9226

RIG_SCORE: 0.7685

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D108V	TCGA-77-7140	LUSC	TCGA	VRPDLGELS	DEG_APCC_DBOX_1	0.0556
p.D108V	DO26455	LUSC	ICGC	VRPDLGELS	DEG_APCC_DBOX_1	0.0556
p.K130T	TCGA-AP-A1DV	UCEC	TCGA	VRPDLGELS	DEG_APCC_DBOX_1	0.3333
p.K130T	DO43186	UCEC	ICGC	VRPDLGELS	DEG_APCC_DBOX_1	0.3333
p.S126A	TCGA-B5-A3FA	UCEC	TCGA	VRPDLGELS	DEG_APCC_DBOX_1	0.6477
p.S126A	DO52402	UCEC	ICGC	VRPDLGELS	DEG_APCC_DBOX_1	0.6477
p.R119W	TCGA-D3-A8GL	SKCM	TCGA	VRPDLGELS	DEG_APCC_DBOX_1	0.8634
p.R119W	DO50287	SKCM	ICGC	VRPDLGELS	DEG_APCC_DBOX_1	0.8634
p.P136T	DO229037	LICA	ICGC	VRPDLGELS	DEG_APCC_DBOX_1	0.0556
p.P136T	DO229045	LICA	ICGC	VRPDLGELS	DEG_APCC_DBOX_1	0.0556
p.D121G	DO229268	THCA	ICGC	VRPDLGELS	DEG_APCC_DBOX_1	0.6087
p.D121E	DO229221	THCA	ICGC	VRPDLGELS	DEG_APCC_DBOX_1	0.5647
p.E109K	SIDM01016	T-Lymphoblastic Leukemia	GDSC	VRPDLGELS	DEG_APCC_DBOX_1	0.0833
p.E109K	ACH-000995	Leukemia	CCLE	VRPDLGELS	DEG_APCC_DBOX_1	0.0833
p.E109K	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	VRPDLGELS	DEG_APCC_DBOX_1	0.0833
p.R135Q	SIDM01689	B-Lymphoblastic Leukemia	GDSC	VRPDLGELS	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51970	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8	DEG_APCC_DBOX_1	118:126	VRPDLGELS	APC,CDC20,FZR1	0.8653	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons