DegronMD - P52272(HNRNPM)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A595T	TCGA-D1-A103	UCEC	TCGA	ERMGLERMG	DEG_APCC_DBOX_1	577:585	Mutation rewiring degron network	0.0556
p.A573T	TCGA-DF-A2KU	UCEC	TCGA	ERMGLERMG	DEG_APCC_DBOX_1	577:585	Mutation rewiring degron network	0.2222
p.R583C	TCGA-E6-A2P9	UCEC	TCGA	ERMGLERMG	DEG_APCC_DBOX_1	577:585	Mutation altering degron motif	0.719
p.R591P	TCGA-L5-A8NH	ESCA	TCGA	ERMGLERMG	DEG_APCC_DBOX_1	577:585	Mutation rewiring degron network	0.1667
p.R583H	TCGA-VQ-A8P2	STAD	TCGA	ERMGLERMG	DEG_APCC_DBOX_1	577:585	Mutation altering degron motif	0.7133
p.R583H	SIDM00217	Colorectal Carcinoma	GDSC	ERMGLERMG	DEG_APCC_DBOX_1	577:585	Mutation altering degron motif	0.7133
p.R583H	ACH-000999	Colon/Colorectal Cancer	CCLE	ERMGLERMG	DEG_APCC_DBOX_1	577:585	Mutation altering degron motif	0.7133
p.R583H	SNU-1040	large intestine	COSMIC	ERMGLERMG	DEG_APCC_DBOX_1	577:585	Mutation altering degron motif	0.7133
p.A586T	TCGA-VQ-A8PP	STAD	TCGA	ERMGLERMG	DEG_APCC_DBOX_1	577:585	Mutation rewiring degron network	0.3056
p.A586T	SIDM00451	T-Lymphoblastic Leukemia	GDSC	ERMGLERMG	DEG_APCC_DBOX_1	577:585	Mutation rewiring degron network	0.3056
p.A586T	ACH-000937	Leukemia	CCLE	ERMGLERMG	DEG_APCC_DBOX_1	577:585	Mutation rewiring degron network	0.3056
p.A586T	PF-382	haematopoietic and lymphoid tissue	COSMIC	ERMGLERMG	DEG_APCC_DBOX_1	577:585	Mutation rewiring degron network	0.3056
p.G577S	DO20891	KIRP	ICGC	ERMGLERMG	DEG_APCC_DBOX_1	577:585	Mutation altering degron motif	0.6993
p.A571T	DO51761	STAD	ICGC	ERMGLERMG	DEG_APCC_DBOX_1	577:585	Mutation rewiring degron network	0.1667
p.R567H	DO222332	STAD	ICGC	ERMGLERMG	DEG_APCC_DBOX_1	577:585	Mutation rewiring degron network	0.0556
p.R567C	DO42552	UCEC	ICGC	ERMGLERMG	DEG_APCC_DBOX_1	577:585	Mutation rewiring degron network	0.0556
p.N574K	SIDM00993	Plasma Cell Myeloma	GDSC	ERMGLERMG	DEG_APCC_DBOX_1	577:585	Mutation rewiring degron network	0.25
p.N574K	ACH-000838	Myeloma	CCLE	ERMGLERMG	DEG_APCC_DBOX_1	577:585	Mutation rewiring degron network	0.25
p.N574K	AMO-1	haematopoietic and lymphoid tissue	COSMIC	ERMGLERMG	DEG_APCC_DBOX_1	577:585	Mutation rewiring degron network	0.25
p.A586S	SIDM00524	Small Cell Lung Carcinoma	GDSC	ERMGLERMG	DEG_APCC_DBOX_1	577:585	Mutation rewiring degron network	0.3056
p.A586S	ACH-000703	Lung Cancer	CCLE	ERMGLERMG	DEG_APCC_DBOX_1	577:585	Mutation rewiring degron network	0.3056
p.A586S	DMS-79	lung	COSMIC	ERMGLERMG	DEG_APCC_DBOX_1	577:585	Mutation rewiring degron network	0.3056
p.R578C	SIDM00220	Ovarian Carcinoma	GDSC	ERMGLERMG	DEG_APCC_DBOX_1	577:585	Mutation altering degron motif	0.8301
p.R578C	ACH-000962	Ovarian Cancer	CCLE	ERMGLERMG	DEG_APCC_DBOX_1	577:585	Mutation altering degron motif	0.8301
p.R578C	ACH-001145	Ovarian Cancer	CCLE	ERMGLERMG	DEG_APCC_DBOX_1	577:585	Mutation altering degron motif	0.8301
p.R578C	OC-314	ovary	COSMIC	ERMGLERMG	DEG_APCC_DBOX_1	577:585	Mutation altering degron motif	0.8301
p.G592R	SNU-1040	large intestine	COSMIC	ERMGLERMG	DEG_APCC_DBOX_1	577:585	Mutation rewiring degron network	0.1389
p.G592R	T47D	breast	COSMIC	ERMGLERMG	DEG_APCC_DBOX_1	577:585	Mutation rewiring degron network	0.1389

Kaplan plot for HNRNPM in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HNRNPM

UniProt ID: P52272

Entrez ID: 4670

Protein name: Heterogeneous nuclear ribonucleoprotein M (hnRNP M)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HNRNPM in