DegronMD

Uniprot ID: P52272

Source protein: Heterogeneous nuclear ribonucleoprotein M

Source gene: HNRNPM

Class: DEG_APCC_DBOX_1

Location: 577:585

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9668

ASA_SCORE: 80.7667

COIL: 0.5134

CONS_SCORE: 0.3787

DSS_SCORE: 0.4866

HELIX: 0.3732

FCONS_SCORE: 1.0483

RIG_SCORE: 0.7268

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A595T	TCGA-D1-A103	UCEC	TCGA	ERMGLERMG	DEG_APCC_DBOX_1	0.0556
p.A573T	TCGA-DF-A2KU	UCEC	TCGA	ERMGLERMG	DEG_APCC_DBOX_1	0.2222
p.R583C	TCGA-E6-A2P9	UCEC	TCGA	ERMGLERMG	DEG_APCC_DBOX_1	0.719
p.R591P	TCGA-L5-A8NH	ESCA	TCGA	ERMGLERMG	DEG_APCC_DBOX_1	0.1667
p.R583H	TCGA-VQ-A8P2	STAD	TCGA	ERMGLERMG	DEG_APCC_DBOX_1	0.7133
p.R583H	SIDM00217	Colorectal Carcinoma	GDSC	ERMGLERMG	DEG_APCC_DBOX_1	0.7133
p.R583H	ACH-000999	Colon/Colorectal Cancer	CCLE	ERMGLERMG	DEG_APCC_DBOX_1	0.7133
p.R583H	SNU-1040	large_intestine	COSMIC	ERMGLERMG	DEG_APCC_DBOX_1	0.7133
p.A586T	TCGA-VQ-A8PP	STAD	TCGA	ERMGLERMG	DEG_APCC_DBOX_1	0.3056
p.A586T	SIDM00451	T-Lymphoblastic Leukemia	GDSC	ERMGLERMG	DEG_APCC_DBOX_1	0.3056
p.A586T	ACH-000937	Leukemia	CCLE	ERMGLERMG	DEG_APCC_DBOX_1	0.3056
p.A586T	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	ERMGLERMG	DEG_APCC_DBOX_1	0.3056
p.G577S	DO20891	KIRP	ICGC	ERMGLERMG	DEG_APCC_DBOX_1	0.6993
p.A571T	DO51761	STAD	ICGC	ERMGLERMG	DEG_APCC_DBOX_1	0.1667
p.R567H	DO222332	STAD	ICGC	ERMGLERMG	DEG_APCC_DBOX_1	0.0556
p.R567C	DO42552	UCEC	ICGC	ERMGLERMG	DEG_APCC_DBOX_1	0.0556
p.N574K	SIDM00993	Plasma Cell Myeloma	GDSC	ERMGLERMG	DEG_APCC_DBOX_1	0.25
p.N574K	ACH-000838	Myeloma	CCLE	ERMGLERMG	DEG_APCC_DBOX_1	0.25
p.N574K	AMO-1	haematopoietic_and_lymphoid_tissue	COSMIC	ERMGLERMG	DEG_APCC_DBOX_1	0.25
p.A586S	SIDM00524	Small Cell Lung Carcinoma	GDSC	ERMGLERMG	DEG_APCC_DBOX_1	0.3056
p.A586S	ACH-000703	Lung Cancer	CCLE	ERMGLERMG	DEG_APCC_DBOX_1	0.3056
p.A586S	DMS-79	lung	COSMIC	ERMGLERMG	DEG_APCC_DBOX_1	0.3056
p.R578C	SIDM00220	Ovarian Carcinoma	GDSC	ERMGLERMG	DEG_APCC_DBOX_1	0.8301
p.R578C	ACH-000962	Ovarian Cancer	CCLE	ERMGLERMG	DEG_APCC_DBOX_1	0.8301
p.R578C	ACH-001145	Ovarian Cancer	CCLE	ERMGLERMG	DEG_APCC_DBOX_1	0.8301
p.R578C	OC-314	ovary	COSMIC	ERMGLERMG	DEG_APCC_DBOX_1	0.8301
p.G592R	SNU-1040	large_intestine	COSMIC	ERMGLERMG	DEG_APCC_DBOX_1	0.1389
p.G592R	T47D	breast	COSMIC	ERMGLERMG	DEG_APCC_DBOX_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ERMGLERMG

Degron related mutations and impact score

Drug responses associated with HNRNPM mutations

All proteins holding degron of ERMGLERMG

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P52272	Heterogeneous nuclear ribonucleoprotein M	DEG_APCC_DBOX_1	577:585	ERMGLERMG	APC,CDC20,FZR1	0.9668	More...