DegronMD - P52739(ZNF131)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E609Q	DO25280	LUAD	ICGC	DRTALPVLE	DEG_APCC_DBOX_1	615:623	Mutation rewiring degron network	0.1667
p.R616K	DO29960	OV	ICGC	DRTALPVLE	DEG_APCC_DBOX_1	615:623	Mutation altering degron motif	0.7237
p.E607D	DO41572	UCEC	ICGC	DRTALPVLE	DEG_APCC_DBOX_1	615:623	Mutation rewiring degron network	0.1111
p.D605N	SIDM00969	Ovarian Carcinoma	GDSC	DRTALPVLE	DEG_APCC_DBOX_1	615:623	Mutation rewiring degron network	0.0556
p.D605N	SIDM00032	Bladder Carcinoma	GDSC	DRTALPVLE	DEG_APCC_DBOX_1	615:623	Mutation rewiring degron network	0.0556
p.D605N	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	DRTALPVLE	DEG_APCC_DBOX_1	615:623	Mutation rewiring degron network	0.0556
p.D605N	SIDM00431	T-Lymphoblastic Leukemia	GDSC	DRTALPVLE	DEG_APCC_DBOX_1	615:623	Mutation rewiring degron network	0.0556

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons