DegronMD

Uniprot ID: P52739

Source protein: Zinc finger protein 131

Source gene: ZNF131

Class: DEG_APCC_DBOX_1

Location: 615:623

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8462

ASA_SCORE: 99.8556

COIL: 0.8921

CONS_SCORE: 0.4351

DSS_SCORE: 0.8909

HELIX: 0.0706

FCONS_SCORE: 1.0068

RIG_SCORE: 0.763

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E609Q	DO25280	LUAD	ICGC	DRTALPVLE	DEG_APCC_DBOX_1	0.1667
p.R616K	DO29960	OV	ICGC	DRTALPVLE	DEG_APCC_DBOX_1	0.7237
p.E607D	DO41572	UCEC	ICGC	DRTALPVLE	DEG_APCC_DBOX_1	0.1111
p.D605N	SIDM00969	Ovarian Carcinoma	GDSC	DRTALPVLE	DEG_APCC_DBOX_1	0.0556
p.D605N	SIDM00032	Bladder Carcinoma	GDSC	DRTALPVLE	DEG_APCC_DBOX_1	0.0556
p.D605N	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	DRTALPVLE	DEG_APCC_DBOX_1	0.0556
p.D605N	SIDM00431	T-Lymphoblastic Leukemia	GDSC	DRTALPVLE	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P52739	Zinc finger protein 131	DEG_APCC_DBOX_1	615:623	DRTALPVLE	APC,CDC20,FZR1	0.8462	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons