DegronMD - P52742(ZNF135)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D152N	TCGA-77-A5GA	LUSC	TCGA	PVKTPVLE	DEG_SCF_FBW7_2	151:158	Mutation altering degron motif	0.6932
p.W159L	TCGA-97-8547	LUAD	TCGA	PVKTPVLE	DEG_SCF_FBW7_2	151:158	Mutation rewiring degron network	0.3056
p.E158K	TCGA-AA-3510	COAD	TCGA	PVKTPVLE	DEG_SCF_FBW7_2	151:158	Mutation altering degron motif	0.7022
p.E151K	TCGA-AD-6895	COAD	TCGA	PVKTPVLE	DEG_SCF_FBW7_2	151:158	Mutation altering degron motif	0.7022
p.T154M	DO10582	COAD	ICGC	PVKTPVLE	DEG_SCF_FBW7_2	151:158	Mutation altering degron motif	0.7423
p.T154M	DO13252	GBM	ICGC	PVKTPVLE	DEG_SCF_FBW7_2	151:158	Mutation altering degron motif	0.7423
p.T154M	DO51761	STAD	ICGC	PVKTPVLE	DEG_SCF_FBW7_2	151:158	Mutation altering degron motif	0.7423
p.K153T	DO50450	ESAD	ICGC	PVKTPVLE	DEG_SCF_FBW7_2	151:158	Mutation altering degron motif	0.6195
p.T154K	DO26479	LUSC	ICGC	PVKTPVLE	DEG_SCF_FBW7_2	151:158	Mutation altering degron motif	0.7306
p.V156L	DO26790	LUSC	ICGC	PVKTPVLE	DEG_SCF_FBW7_2	151:158	Mutation altering degron motif	0.5654
p.G164W	DO37916	SKCM	ICGC	PVKTPVLE	DEG_SCF_FBW7_2	151:158	Mutation rewiring degron network	0.1667
p.P151H	DO229259	THCA	ICGC	PVKTPVLE	DEG_SCF_FBW7_2	151:158	Mutation altering degron motif	0.7694
p.T150M	DO41903	UCEC	ICGC	PVKTPVLE	DEG_SCF_FBW7_2	151:158	Mutation rewiring degron network	0.3056
p.E154D	SIDM00617	Hepatocellular Carcinoma	GDSC	PVKTPVLE	DEG_SCF_FBW7_2	151:158	Mutation altering degron motif	0.6758
p.E154D	JHH-2	liver	COSMIC	PVKTPVLE	DEG_SCF_FBW7_2	151:158	Mutation altering degron motif	0.6758
p.T153S	SIDM00705	Non-Cancerous	GDSC	PVKTPVLE	DEG_SCF_FBW7_2	151:158	Mutation altering degron motif	0.7116
p.T153S	SIDM00696	Non-Cancerous	GDSC	PVKTPVLE	DEG_SCF_FBW7_2	151:158	Mutation altering degron motif	0.7116
p.T153S	SIDM00772	Breast Carcinoma	GDSC	PVKTPVLE	DEG_SCF_FBW7_2	151:158	Mutation altering degron motif	0.7116
p.G150C	SIDM01087	Melanoma	GDSC	PVKTPVLE	DEG_SCF_FBW7_2	151:158	Mutation rewiring degron network	0.3056
p.G144R	SIDM00813	Non-Cancerous	GDSC	PVKTPVLE	DEG_SCF_FBW7_2	151:158	Mutation rewiring degron network	0.1389
p.G144R	RPMI-6666	haematopoietic and lymphoid tissue	COSMIC	PVKTPVLE	DEG_SCF_FBW7_2	151:158	Mutation rewiring degron network	0.1389
p.E165D	SIDM00032	Bladder Carcinoma	GDSC	PVKTPVLE	DEG_SCF_FBW7_2	151:158	Mutation rewiring degron network	0.1389
p.E165D	SCaBER	urinary tract	COSMIC	PVKTPVLE	DEG_SCF_FBW7_2	151:158	Mutation rewiring degron network	0.1389
p.Y147C	SIDM00783	Colorectal Carcinoma	GDSC	PVKTPVLE	DEG_SCF_FBW7_2	151:158	Mutation rewiring degron network	0.2222
p.Y147C	HCT-116	large intestine	COSMIC	PVKTPVLE	DEG_SCF_FBW7_2	151:158	Mutation rewiring degron network	0.2222
p.E141V	ACH-000941	Endometrial/Uterine Cancer	CCLE	PVKTPVLE	DEG_SCF_FBW7_2	151:158	Mutation rewiring degron network	0.0556
p.E141V	ACH-001517	Endometrial/Uterine Cancer	CCLE	PVKTPVLE	DEG_SCF_FBW7_2	151:158	Mutation rewiring degron network	0.0556
p.E141V	HEC-1	endometrium	COSMIC	PVKTPVLE	DEG_SCF_FBW7_2	151:158	Mutation rewiring degron network	0.0556
p.Q163R	ACH-002272	Lymphoma	CCLE	PVKTPVLE	DEG_SCF_FBW7_2	151:158	Mutation rewiring degron network	0.1944
p.Q163R	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	PVKTPVLE	DEG_SCF_FBW7_2	151:158	Mutation rewiring degron network	0.1944
p.E141D	SCaBER	urinary tract	COSMIC	PVKTPVLE	DEG_SCF_FBW7_2	151:158	Mutation rewiring degron network	0.0556
p.E153D	SCaBER	urinary tract	COSMIC	PVKTPVLE	DEG_SCF_FBW7_2	151:158	Mutation altering degron motif	0.6758
p.E142D	JHH-2	liver	COSMIC	PVKTPVLE	DEG_SCF_FBW7_2	151:158	Mutation rewiring degron network	0.0833

Kaplan plot for ZNF135 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF135

UniProt ID: P52742

Entrez ID: 7694

Protein name: Zinc finger protein 135 (Zinc finger protein 61) (Zinc finger protein 78-like 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF135 in