DegronMD

Uniprot ID: P52742

Source protein: Zinc finger protein 135

Source gene: ZNF135

Class: DEG_SCF_FBW7_2

Location: 151:158

E3 ligase: FBXW7

DEGRON score: 0.6338

ASA_SCORE: 95.3

COIL: 0.8285

CONS_SCORE: 0.4291

DSS_SCORE: 0.3377

HELIX: 0.0301

FCONS_SCORE: 1.0014

RIG_SCORE: 0.832

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D152N	TCGA-77-A5GA	LUSC	TCGA	PVKTPVLE	DEG_SCF_FBW7_2	0.6932
p.W159L	TCGA-97-8547	LUAD	TCGA	PVKTPVLE	DEG_SCF_FBW7_2	0.3056
p.E158K	TCGA-AA-3510	COAD	TCGA	PVKTPVLE	DEG_SCF_FBW7_2	0.7022
p.E151K	TCGA-AD-6895	COAD	TCGA	PVKTPVLE	DEG_SCF_FBW7_2	0.7022
p.T154M	DO10582	COAD	ICGC	PVKTPVLE	DEG_SCF_FBW7_2	0.7423
p.T154M	DO13252	GBM	ICGC	PVKTPVLE	DEG_SCF_FBW7_2	0.7423
p.T154M	DO51761	STAD	ICGC	PVKTPVLE	DEG_SCF_FBW7_2	0.7423
p.K153T	DO50450	ESAD	ICGC	PVKTPVLE	DEG_SCF_FBW7_2	0.6195
p.T154K	DO26479	LUSC	ICGC	PVKTPVLE	DEG_SCF_FBW7_2	0.7306
p.V156L	DO26790	LUSC	ICGC	PVKTPVLE	DEG_SCF_FBW7_2	0.5654
p.G164W	DO37916	SKCM	ICGC	PVKTPVLE	DEG_SCF_FBW7_2	0.1667
p.P151H	DO229259	THCA	ICGC	PVKTPVLE	DEG_SCF_FBW7_2	0.7694
p.T150M	DO41903	UCEC	ICGC	PVKTPVLE	DEG_SCF_FBW7_2	0.3056
p.E154D	SIDM00617	Hepatocellular Carcinoma	GDSC	PVKTPVLE	DEG_SCF_FBW7_2	0.6758
p.E154D	JHH-2	liver	COSMIC	PVKTPVLE	DEG_SCF_FBW7_2	0.6758
p.T153S	SIDM00705	Non-Cancerous	GDSC	PVKTPVLE	DEG_SCF_FBW7_2	0.7116
p.T153S	SIDM00696	Non-Cancerous	GDSC	PVKTPVLE	DEG_SCF_FBW7_2	0.7116
p.T153S	SIDM00772	Breast Carcinoma	GDSC	PVKTPVLE	DEG_SCF_FBW7_2	0.7116
p.G150C	SIDM01087	Melanoma	GDSC	PVKTPVLE	DEG_SCF_FBW7_2	0.3056
p.G144R	SIDM00813	Non-Cancerous	GDSC	PVKTPVLE	DEG_SCF_FBW7_2	0.1389
p.G144R	RPMI-6666	haematopoietic_and_lymphoid_tissue	COSMIC	PVKTPVLE	DEG_SCF_FBW7_2	0.1389
p.E165D	SIDM00032	Bladder Carcinoma	GDSC	PVKTPVLE	DEG_SCF_FBW7_2	0.1389
p.E165D	SCaBER	urinary_tract	COSMIC	PVKTPVLE	DEG_SCF_FBW7_2	0.1389
p.Y147C	SIDM00783	Colorectal Carcinoma	GDSC	PVKTPVLE	DEG_SCF_FBW7_2	0.2222
p.Y147C	HCT-116	large_intestine	COSMIC	PVKTPVLE	DEG_SCF_FBW7_2	0.2222
p.E141V	ACH-000941	Endometrial/Uterine Cancer	CCLE	PVKTPVLE	DEG_SCF_FBW7_2	0.0556
p.E141V	ACH-001517	Endometrial/Uterine Cancer	CCLE	PVKTPVLE	DEG_SCF_FBW7_2	0.0556
p.E141V	HEC-1	endometrium	COSMIC	PVKTPVLE	DEG_SCF_FBW7_2	0.0556
p.Q163R	ACH-002272	Lymphoma	CCLE	PVKTPVLE	DEG_SCF_FBW7_2	0.1944
p.Q163R	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	PVKTPVLE	DEG_SCF_FBW7_2	0.1944
p.E141D	SCaBER	urinary_tract	COSMIC	PVKTPVLE	DEG_SCF_FBW7_2	0.0556
p.E153D	SCaBER	urinary_tract	COSMIC	PVKTPVLE	DEG_SCF_FBW7_2	0.6758
p.E142D	JHH-2	liver	COSMIC	PVKTPVLE	DEG_SCF_FBW7_2	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVKTPVLE

Degron related mutations and impact score

Drug responses associated with ZNF135 mutations

All proteins holding degron of PVKTPVLE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P52742	Zinc finger protein 135	DEG_SCF_FBW7_2	151:158	PVKTPVLE	FBXW7	0.6338	More...