DegronMD - P52789(HK2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K510R	TCGA-2W-A8YY	CESC	TCGA	VCATPDGT	DEG_SCF_FBW7_1	516:523	Mutation blocking ubiquitination signal	0.6111
p.V509I	TCGA-67-3771	LUAD	TCGA	VCATPDGT	DEG_SCF_FBW7_1	516:523	Mutation rewiring degron network	0.1389
p.P508S	TCGA-6A-AB49	LUSC	TCGA	VCATPDGT	DEG_SCF_FBW7_1	516:523	Mutation rewiring degron network	0.1111
p.A530V	TCGA-A5-A0G2	UCEC	TCGA	VCATPDGT	DEG_SCF_FBW7_1	516:523	Mutation rewiring degron network	0.1389
p.P508L	TCGA-EE-A29E	SKCM	TCGA	VCATPDGT	DEG_SCF_FBW7_1	516:523	Mutation rewiring degron network	0.1111
p.A533S	DO732	BLCA	ICGC	VCATPDGT	DEG_SCF_FBW7_1	516:523	Mutation rewiring degron network	0.0556
p.R518Q	DO222454	BTCA	ICGC	VCATPDGT	DEG_SCF_FBW7_1	516:523	Mutation altering degron motif	0.7329
p.R518Q	DO234239	ESAD	ICGC	VCATPDGT	DEG_SCF_FBW7_1	516:523	Mutation altering degron motif	0.7329
p.G523D	DO222983	BTCA	ICGC	VCATPDGT	DEG_SCF_FBW7_1	516:523	Mutation altering degron motif	0.7198
p.F510L	DO51612	CESC	ICGC	VCATPDGT	DEG_SCF_FBW7_1	516:523	Mutation blocking ubiquitination signal	0.6111
p.N509D	DO223732	CESC	ICGC	VCATPDGT	DEG_SCF_FBW7_1	516:523	Mutation rewiring degron network	0.1389
p.R516H	DO51734	COAD	ICGC	VCATPDGT	DEG_SCF_FBW7_1	516:523	Mutation altering degron motif	0.8244
p.M527I	DO229022	LICA	ICGC	VCATPDGT	DEG_SCF_FBW7_1	516:523	Mutation rewiring degron network	0.2222
p.F510I	DO26436	LUSC	ICGC	VCATPDGT	DEG_SCF_FBW7_1	516:523	Mutation blocking ubiquitination signal	0.6111
p.R518W	DO41235	UCEC	ICGC	VCATPDGT	DEG_SCF_FBW7_1	516:523	Mutation altering degron motif	0.8634
p.Y515C	SIDM01078	Small Cell Lung Carcinoma	GDSC	VCATPDGT	DEG_SCF_FBW7_1	516:523	Mutation rewiring degron network	0.3056
p.R516C	ACH-000977	lymph node	CCLE	VCATPDGT	DEG_SCF_FBW7_1	516:523	Mutation altering degron motif	0.8301
p.R516C	LNCaP-Clone-FGC	prostate	COSMIC	VCATPDGT	DEG_SCF_FBW7_1	516:523	Mutation altering degron motif	0.8301
p.P520L	HCC202	breast	COSMIC	VCATPDGT	DEG_SCF_FBW7_1	516:523	Mutation altering degron motif	0.7582
p.P520L	SNU-C2B	large intestine	COSMIC	VCATPDGT	DEG_SCF_FBW7_1	516:523	Mutation altering degron motif	0.7582
p.P520L	GCIY	stomach	COSMIC	VCATPDGT	DEG_SCF_FBW7_1	516:523	Mutation altering degron motif	0.7582

Kaplan plot for HK2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HK2

UniProt ID: P52789

Entrez ID: 3099

Protein name: Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Hexokinase-B) (Muscle form hexokinase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HK2 in