DegronMD

Uniprot ID: P52789

Source protein: Hexokinase-2

Source gene: HK2

Class: DEG_SCF_FBW7_1

Location: 516:523

E3 ligase: FBXW7

DEGRON score: 0.9825

ASA_SCORE: 50.725

COIL: 0.7043

CONS_SCORE: 0.3035

DSS_SCORE: 0.2748

HELIX: 0.041

FCONS_SCORE: 0.9878

RIG_SCORE: 0.7807

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K510R	TCGA-2W-A8YY	CESC	TCGA	VCATPDGT	DEG_SCF_FBW7_1	0.6111
p.V509I	TCGA-67-3771	LUAD	TCGA	VCATPDGT	DEG_SCF_FBW7_1	0.1389
p.P508S	TCGA-6A-AB49	LUSC	TCGA	VCATPDGT	DEG_SCF_FBW7_1	0.1111
p.A530V	TCGA-A5-A0G2	UCEC	TCGA	VCATPDGT	DEG_SCF_FBW7_1	0.1389
p.P508L	TCGA-EE-A29E	SKCM	TCGA	VCATPDGT	DEG_SCF_FBW7_1	0.1111
p.A533S	DO732	BLCA	ICGC	VCATPDGT	DEG_SCF_FBW7_1	0.0556
p.R518Q	DO222454	BTCA	ICGC	VCATPDGT	DEG_SCF_FBW7_1	0.7329
p.R518Q	DO234239	ESAD	ICGC	VCATPDGT	DEG_SCF_FBW7_1	0.7329
p.G523D	DO222983	BTCA	ICGC	VCATPDGT	DEG_SCF_FBW7_1	0.7198
p.F510L	DO51612	CESC	ICGC	VCATPDGT	DEG_SCF_FBW7_1	0.6111
p.N509D	DO223732	CESC	ICGC	VCATPDGT	DEG_SCF_FBW7_1	0.1389
p.R516H	DO51734	COAD	ICGC	VCATPDGT	DEG_SCF_FBW7_1	0.8244
p.M527I	DO229022	LICA	ICGC	VCATPDGT	DEG_SCF_FBW7_1	0.2222
p.F510I	DO26436	LUSC	ICGC	VCATPDGT	DEG_SCF_FBW7_1	0.6111
p.R518W	DO41235	UCEC	ICGC	VCATPDGT	DEG_SCF_FBW7_1	0.8634
p.Y515C	SIDM01078	Small Cell Lung Carcinoma	GDSC	VCATPDGT	DEG_SCF_FBW7_1	0.3056
p.R516C	ACH-000977	lymph_node	CCLE	VCATPDGT	DEG_SCF_FBW7_1	0.8301
p.R516C	LNCaP-Clone-FGC	prostate	COSMIC	VCATPDGT	DEG_SCF_FBW7_1	0.8301
p.P520L	HCC202	breast	COSMIC	VCATPDGT	DEG_SCF_FBW7_1	0.7582
p.P520L	SNU-C2B	large_intestine	COSMIC	VCATPDGT	DEG_SCF_FBW7_1	0.7582
p.P520L	GCIY	stomach	COSMIC	VCATPDGT	DEG_SCF_FBW7_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P52789	Hexokinase-2	DEG_SCF_FBW7_1	516:523	VCATPDGT	FBXW7	0.9825	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons