DegronMD - P52790(HK3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S81P	TCGA-19-5956	GBM	TCGA	VGSTPHGT	DEG_SCF_FBW7_1	79:86	Mutation altering degron motif	0.5641
p.S81P	DO13863	GBM	ICGC	VGSTPHGT	DEG_SCF_FBW7_1	79:86	Mutation altering degron motif	0.5641
p.D90Y	TCGA-A5-A2K5	UCEC	TCGA	VGSTPHGT	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.2222
p.D90Y	TCGA-IB-7651	PAAD	TCGA	VGSTPHGT	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.2222
p.D90Y	DO46657	PAAD	ICGC	VGSTPHGT	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.2222
p.D90Y	DO41379	UCEC	ICGC	VGSTPHGT	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.2222
p.D90Y	SIDM00193	Colorectal Carcinoma	GDSC	VGSTPHGT	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.2222
p.D90Y	ACH-000991	Colon/Colorectal Cancer	CCLE	VGSTPHGT	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.2222
p.D90Y	SNU-81	large intestine	COSMIC	VGSTPHGT	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.2222
p.V79M	TCGA-D1-A17F	UCEC	TCGA	VGSTPHGT	DEG_SCF_FBW7_1	79:86	Mutation altering degron motif	0.6097
p.V79M	DO43362	UCEC	ICGC	VGSTPHGT	DEG_SCF_FBW7_1	79:86	Mutation altering degron motif	0.6097
p.G89E	TCGA-FI-A2D5	UCEC	TCGA	VGSTPHGT	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.25
p.G89E	DO222286	GACA	ICGC	VGSTPHGT	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.25
p.G89E	DO41331	UCEC	ICGC	VGSTPHGT	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.25
p.R73W	TCGA-G4-6306	COAD	TCGA	VGSTPHGT	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.1667
p.R73W	DO8055	COAD	ICGC	VGSTPHGT	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.1667
p.L75M	DO228952	LICA	ICGC	VGSTPHGT	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.2222
p.A69D	DO229037	LICA	ICGC	VGSTPHGT	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.0556
p.P83L	DO232015	ORCA	ICGC	VGSTPHGT	DEG_SCF_FBW7_1	79:86	Mutation altering degron motif	0.7582
p.V72I	DO218863	SKCA	ICGC	VGSTPHGT	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.1389
p.R73Q	SIDM01090	Colorectal Carcinoma	GDSC	VGSTPHGT	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.1667
p.R73Q	SIDM00309	Mesothelioma	GDSC	VGSTPHGT	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.1667
p.R73Q	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	VGSTPHGT	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.1667
p.R73Q	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	VGSTPHGT	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.1667

Kaplan plot for HK3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HK3

UniProt ID: P52790

Entrez ID: 3101

Protein name: Hexokinase-3 (EC 2.7.1.1) (Hexokinase type III) (HK III) (Hexokinase-C)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HK3 in