DegronMD

Uniprot ID: P52790

Source protein: Hexokinase-3

Source gene: HK3

Class: DEG_SCF_FBW7_1

Location: 79:86

E3 ligase: FBXW7

DEGRON score: 0.6273

ASA_SCORE: 55.275

COIL: 0.6671

CONS_SCORE: 0.26

DSS_SCORE: 0.3935

HELIX: 0.0274

FCONS_SCORE: 0.9998

RIG_SCORE: 0.6591

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S81P	TCGA-19-5956	GBM	TCGA	VGSTPHGT	DEG_SCF_FBW7_1	0.5641
p.S81P	DO13863	GBM	ICGC	VGSTPHGT	DEG_SCF_FBW7_1	0.5641
p.D90Y	TCGA-A5-A2K5	UCEC	TCGA	VGSTPHGT	DEG_SCF_FBW7_1	0.2222
p.D90Y	TCGA-IB-7651	PAAD	TCGA	VGSTPHGT	DEG_SCF_FBW7_1	0.2222
p.D90Y	DO46657	PAAD	ICGC	VGSTPHGT	DEG_SCF_FBW7_1	0.2222
p.D90Y	DO41379	UCEC	ICGC	VGSTPHGT	DEG_SCF_FBW7_1	0.2222
p.D90Y	SIDM00193	Colorectal Carcinoma	GDSC	VGSTPHGT	DEG_SCF_FBW7_1	0.2222
p.D90Y	ACH-000991	Colon/Colorectal Cancer	CCLE	VGSTPHGT	DEG_SCF_FBW7_1	0.2222
p.D90Y	SNU-81	large_intestine	COSMIC	VGSTPHGT	DEG_SCF_FBW7_1	0.2222
p.V79M	TCGA-D1-A17F	UCEC	TCGA	VGSTPHGT	DEG_SCF_FBW7_1	0.6097
p.V79M	DO43362	UCEC	ICGC	VGSTPHGT	DEG_SCF_FBW7_1	0.6097
p.G89E	TCGA-FI-A2D5	UCEC	TCGA	VGSTPHGT	DEG_SCF_FBW7_1	0.25
p.G89E	DO222286	GACA	ICGC	VGSTPHGT	DEG_SCF_FBW7_1	0.25
p.G89E	DO41331	UCEC	ICGC	VGSTPHGT	DEG_SCF_FBW7_1	0.25
p.R73W	TCGA-G4-6306	COAD	TCGA	VGSTPHGT	DEG_SCF_FBW7_1	0.1667
p.R73W	DO8055	COAD	ICGC	VGSTPHGT	DEG_SCF_FBW7_1	0.1667
p.L75M	DO228952	LICA	ICGC	VGSTPHGT	DEG_SCF_FBW7_1	0.2222
p.A69D	DO229037	LICA	ICGC	VGSTPHGT	DEG_SCF_FBW7_1	0.0556
p.P83L	DO232015	ORCA	ICGC	VGSTPHGT	DEG_SCF_FBW7_1	0.7582
p.V72I	DO218863	SKCA	ICGC	VGSTPHGT	DEG_SCF_FBW7_1	0.1389
p.R73Q	SIDM01090	Colorectal Carcinoma	GDSC	VGSTPHGT	DEG_SCF_FBW7_1	0.1667
p.R73Q	SIDM00309	Mesothelioma	GDSC	VGSTPHGT	DEG_SCF_FBW7_1	0.1667
p.R73Q	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	VGSTPHGT	DEG_SCF_FBW7_1	0.1667
p.R73Q	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	VGSTPHGT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P52790	Hexokinase-3	DEG_SCF_FBW7_1	79:86	VGSTPHGT	FBXW7	0.6273	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons