DegronMD - P52797(EFNA3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V165I	TCGA-06-5416	GBM	TCGA	SGEKPVPTL	DEG_COP1_1	173:181	Mutation rewiring degron network	0.1111
p.V165I	DO10880	GBM	ICGC	SGEKPVPTL	DEG_COP1_1	173:181	Mutation rewiring degron network	0.1111
p.S171W	TCGA-52-7810	LUSC	TCGA	SGEKPVPTL	DEG_COP1_1	173:181	Mutation rewiring degron network	0.2778
p.S171W	DO27381	LUSC	ICGC	SGEKPVPTL	DEG_COP1_1	173:181	Mutation rewiring degron network	0.2778
p.P179H	TCGA-AA-3947	COAD	TCGA	SGEKPVPTL	DEG_COP1_1	173:181	Mutation altering degron motif	0.7694
p.P179H	DO8192	COAD	ICGC	SGEKPVPTL	DEG_COP1_1	173:181	Mutation altering degron motif	0.7694
p.P182L	TCGA-BK-A13B	UCEC	TCGA	SGEKPVPTL	DEG_COP1_1	173:181	Mutation rewiring degron network	0.3056
p.P182L	DO40825	UCEC	ICGC	SGEKPVPTL	DEG_COP1_1	173:181	Mutation rewiring degron network	0.3056
p.P182H	TCGA-FS-A1ZJ	SKCM	TCGA	SGEKPVPTL	DEG_COP1_1	173:181	Mutation rewiring degron network	0.3056
p.P182H	DO37956	SKCM	ICGC	SGEKPVPTL	DEG_COP1_1	173:181	Mutation rewiring degron network	0.3056
p.T180I	TCGA-TM-A7C3	LGG	TCGA	SGEKPVPTL	DEG_COP1_1	173:181	Mutation altering degron motif	0.7078
p.T180I	DO50222	LGG	ICGC	SGEKPVPTL	DEG_COP1_1	173:181	Mutation altering degron motif	0.7078
p.P174H	DO8192	COAD	ICGC	SGEKPVPTL	DEG_COP1_1	173:181	Mutation altering degron motif	0.7694
p.V190M	DO229013	COCA	ICGC	SGEKPVPTL	DEG_COP1_1	173:181	Mutation rewiring degron network	0.0833
p.V185M	DO229013	COCA	ICGC	SGEKPVPTL	DEG_COP1_1	173:181	Mutation rewiring degron network	0.2222
p.T175I	DO50222	LGG	ICGC	SGEKPVPTL	DEG_COP1_1	173:181	Mutation altering degron motif	0.7078
p.T170A	DO50831	LIRI	ICGC	SGEKPVPTL	DEG_COP1_1	173:181	Mutation rewiring degron network	0.25
p.T165A	DO50831	LIRI	ICGC	SGEKPVPTL	DEG_COP1_1	173:181	Mutation rewiring degron network	0.1111
p.S166W	DO27381	LUSC	ICGC	SGEKPVPTL	DEG_COP1_1	173:181	Mutation rewiring degron network	0.1389
p.P177H	DO37956	SKCM	ICGC	SGEKPVPTL	DEG_COP1_1	173:181	Mutation altering degron motif	0.6583
p.P177L	DO40825	UCEC	ICGC	SGEKPVPTL	DEG_COP1_1	173:181	Mutation altering degron motif	0.6471
p.L190M	DO42665	UCEC	ICGC	SGEKPVPTL	DEG_COP1_1	173:181	Mutation rewiring degron network	0.0833
p.N189D	SIDM00981	B-Cell Non-Hodgkin's Lymphoma	GDSC	SGEKPVPTL	DEG_COP1_1	173:181	Mutation rewiring degron network	0.1111
p.N189D	SIDM00481	Ovarian Carcinoma	GDSC	SGEKPVPTL	DEG_COP1_1	173:181	Mutation rewiring degron network	0.1111
p.N189D	DOHH-2	haematopoietic and lymphoid tissue	COSMIC	SGEKPVPTL	DEG_COP1_1	173:181	Mutation rewiring degron network	0.1111
p.N189D	OAW-28	ovary	COSMIC	SGEKPVPTL	DEG_COP1_1	173:181	Mutation rewiring degron network	0.1111
p.C166Y	SIDM00789	Colorectal Carcinoma	GDSC	SGEKPVPTL	DEG_COP1_1	173:181	Mutation rewiring degron network	0.1389
p.C166Y	HCT-15	large intestine	COSMIC	SGEKPVPTL	DEG_COP1_1	173:181	Mutation rewiring degron network	0.1389

Kaplan plot for EFNA3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EFNA3

UniProt ID: P52797

Entrez ID: 1944

Protein name: Ephrin-A3 (EFL-2) (EHK1 ligand) (EHK1-L) (EPH-related receptor tyrosine kinase ligand 3) (LERK-3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EFNA3 in