DegronMD

Uniprot ID: P52797

Source protein: Ephrin-A3

Source gene: EFNA3

Class: DEG_COP1_1

Location: 173:181

E3 ligase: COP1

DEGRON score: 0.5724

ASA_SCORE: 90.1333

COIL: 0.9166

CONS_SCORE: 0.6088

DSS_SCORE: 0.372

HELIX: 0.019

FCONS_SCORE: 0.9466

RIG_SCORE: 0.7013

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V165I	TCGA-06-5416	GBM	TCGA	SGEKPVPTL	DEG_COP1_1	0.1111
p.V165I	DO10880	GBM	ICGC	SGEKPVPTL	DEG_COP1_1	0.1111
p.S171W	TCGA-52-7810	LUSC	TCGA	SGEKPVPTL	DEG_COP1_1	0.2778
p.S171W	DO27381	LUSC	ICGC	SGEKPVPTL	DEG_COP1_1	0.2778
p.P179H	TCGA-AA-3947	COAD	TCGA	SGEKPVPTL	DEG_COP1_1	0.7694
p.P179H	DO8192	COAD	ICGC	SGEKPVPTL	DEG_COP1_1	0.7694
p.P182L	TCGA-BK-A13B	UCEC	TCGA	SGEKPVPTL	DEG_COP1_1	0.3056
p.P182L	DO40825	UCEC	ICGC	SGEKPVPTL	DEG_COP1_1	0.3056
p.P182H	TCGA-FS-A1ZJ	SKCM	TCGA	SGEKPVPTL	DEG_COP1_1	0.3056
p.P182H	DO37956	SKCM	ICGC	SGEKPVPTL	DEG_COP1_1	0.3056
p.T180I	TCGA-TM-A7C3	LGG	TCGA	SGEKPVPTL	DEG_COP1_1	0.7078
p.T180I	DO50222	LGG	ICGC	SGEKPVPTL	DEG_COP1_1	0.7078
p.P174H	DO8192	COAD	ICGC	SGEKPVPTL	DEG_COP1_1	0.7694
p.V190M	DO229013	COCA	ICGC	SGEKPVPTL	DEG_COP1_1	0.0833
p.V185M	DO229013	COCA	ICGC	SGEKPVPTL	DEG_COP1_1	0.2222
p.T175I	DO50222	LGG	ICGC	SGEKPVPTL	DEG_COP1_1	0.7078
p.T170A	DO50831	LIRI	ICGC	SGEKPVPTL	DEG_COP1_1	0.25
p.T165A	DO50831	LIRI	ICGC	SGEKPVPTL	DEG_COP1_1	0.1111
p.S166W	DO27381	LUSC	ICGC	SGEKPVPTL	DEG_COP1_1	0.1389
p.P177H	DO37956	SKCM	ICGC	SGEKPVPTL	DEG_COP1_1	0.6583
p.P177L	DO40825	UCEC	ICGC	SGEKPVPTL	DEG_COP1_1	0.6471
p.L190M	DO42665	UCEC	ICGC	SGEKPVPTL	DEG_COP1_1	0.0833
p.N189D	SIDM00981	B-Cell Non-Hodgkin's Lymphoma	GDSC	SGEKPVPTL	DEG_COP1_1	0.1111
p.N189D	SIDM00481	Ovarian Carcinoma	GDSC	SGEKPVPTL	DEG_COP1_1	0.1111
p.N189D	DOHH-2	haematopoietic_and_lymphoid_tissue	COSMIC	SGEKPVPTL	DEG_COP1_1	0.1111
p.N189D	OAW-28	ovary	COSMIC	SGEKPVPTL	DEG_COP1_1	0.1111
p.C166Y	SIDM00789	Colorectal Carcinoma	GDSC	SGEKPVPTL	DEG_COP1_1	0.1389
p.C166Y	HCT-15	large_intestine	COSMIC	SGEKPVPTL	DEG_COP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P52797	Ephrin-A3	DEG_COP1_1	173:181	SGEKPVPTL	COP1	0.5724	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SGEKPVPTL

Degron related mutations and impact score

Drug responses associated with EFNA3 mutations

All proteins holding degron of SGEKPVPTL