FUNCTION: [Isoform 1]: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate (PubMed:9230113, PubMed:9744796, PubMed:35137078). Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to ma...
FUNCTION: [Isoform 1]: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate (PubMed:9230113, PubMed:9744796, PubMed:35137078). Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis (PubMed:9230113). Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response (By similarity). Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). {ECO:0000250|UniProtKB:Q3UHN9, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:9230113}.; FUNCTION: [Isoform 3]: Lacks both N-deacetylase and N-sulfotransferase activities. Acts as a dominant negative on isoform 1, likely by changing the composition of enzyme complexes responsible for elongation and modification of heparan sulfates. {ECO:0000269|PubMed:35137078}.
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GO - Biological processes (BP):
aorta development [GO:0035904]; cardiac septum development [GO:0003279]; cell population proliferation [GO:0008283]; coronary vasculature development [GO:0060976]; embryonic neurocranium morphogenesis [GO:0048702]; embryonic viscerocranium morphogenesis [GO:0048703]; fibroblast growth factor recepto...
aorta development [GO:0035904]; cardiac septum development [GO:0003279]; cell population proliferation [GO:0008283]; coronary vasculature development [GO:0060976]; embryonic neurocranium morphogenesis [GO:0048702]; embryonic viscerocranium morphogenesis [GO:0048703]; fibroblast growth factor receptor signaling pathway [GO:0008543]; forebrain development [GO:0030900]; glycosaminoglycan biosynthetic process [GO:0006024]; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0015014]; heparin biosynthetic process [GO:0030210]; inflammatory response [GO:0006954]; midbrain development [GO:0030901]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of smoothened signaling pathway [GO:0045880]; protein sulfation [GO:0006477]; respiratory gaseous exchange by respiratory system [GO:0007585]
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GO - Molecular function (MF):
[heparan sulfate]-glucosamine N-sulfotransferase activity [GO:0015016]; deacetylase activity [GO:0019213]; heparan sulfate N-deacetylase activity [GO:0102140]; N-acetylglucosamine deacetylase activity [GO:0050119]...
[heparan sulfate]-glucosamine N-sulfotransferase activity [GO:0015016]; deacetylase activity [GO:0019213]; heparan sulfate N-deacetylase activity [GO:0102140]; N-acetylglucosamine deacetylase activity [GO:0050119]
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GO - Cellular component (CC):
Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; trans-Golgi network membrane [GO:0032588]...
Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; trans-Golgi network membrane [GO:0032588]
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