DegronMD

Uniprot ID: P52848

Source protein: Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1

Source gene: NDST1

Class: LIG_APCC_ABBA_1

Location: 85:90

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6529

ASA_SCORE: 13.15

COIL: 0.046

CONS_SCORE: 0.531

DSS_SCORE: 0.1122

HELIX: 0.005

FCONS_SCORE: 1.2822

RIG_SCORE: 0.9365

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P78H	TCGA-D7-A6EZ	STAD	TCGA	VLVFVE	LIG_APCC_ABBA_1	0.1389
p.P78H	DO50119	STAD	ICGC	VLVFVE	LIG_APCC_ABBA_1	0.1389
p.R80C	TCGA-NH-A5IV	COAD	TCGA	VLVFVE	LIG_APCC_ABBA_1	0.1944
p.R80C	DO49095	COAD	ICGC	VLVFVE	LIG_APCC_ABBA_1	0.1944
p.R80C	SIDM00063	Melanoma	GDSC	VLVFVE	LIG_APCC_ABBA_1	0.1944
p.G97C	DO229029	LICA	ICGC	VLVFVE	LIG_APCC_ABBA_1	0.1389
p.G97C	DO229031	LICA	ICGC	VLVFVE	LIG_APCC_ABBA_1	0.1389
p.F88L	DO231120	LUSC	ICGC	VLVFVE	LIG_APCC_ABBA_1	0.6981
p.E90D	DO33070	PACA	ICGC	VLVFVE	LIG_APCC_ABBA_1	0.5647
p.T81R	SIDM01473	Plasma Cell Myeloma	GDSC	VLVFVE	LIG_APCC_ABBA_1	0.2222
p.T81R	ACH-000541	Myeloma	CCLE	VLVFVE	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P52848	Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1	LIG_APCC_ABBA_1	85:90	VLVFVE	APC,CDC20,FZR1	0.6529	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons