DegronMD - P52954(LBX1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A27V	TCGA-BR-6452	STAD	TCGA	RRSPLDHLP	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.25
p.A27V	DO38404	STAD	ICGC	RRSPLDHLP	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.25
p.G12W	TCGA-G7-6795	KIRP	TCGA	RRSPLDHLP	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.2222
p.G12W	DO20851	KIRP	ICGC	RRSPLDHLP	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.2222
p.G7C	TCGA-K7-A5RF	LIHC	TCGA	RRSPLDHLP	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.0833
p.G7C	DO52303	LIHC	ICGC	RRSPLDHLP	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.0833
p.R17H	DO233245	GACA	ICGC	RRSPLDHLP	DEG_APCC_DBOX_1	16:24	Mutation altering degron motif	0.8244
p.R16W	DO233709	GACA	ICGC	RRSPLDHLP	DEG_APCC_DBOX_1	16:24	Mutation altering degron motif	0.7523
p.P25L	DO233838	GACA	ICGC	RRSPLDHLP	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.3056
p.R17C	SIDM01088	Endometrial Carcinoma	GDSC	RRSPLDHLP	DEG_APCC_DBOX_1	16:24	Mutation altering degron motif	0.8301
p.R17C	ACH-000965	Endometrial/Uterine Cancer	CCLE	RRSPLDHLP	DEG_APCC_DBOX_1	16:24	Mutation altering degron motif	0.8301
p.S29P	ACH-001331	Head and Neck Cancer	CCLE	RRSPLDHLP	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.1944
p.H22P	ACH-002267	Leukemia	CCLE	RRSPLDHLP	DEG_APCC_DBOX_1	16:24	Mutation altering degron motif	0.6583
p.H22P	ACH-002360	Non-Cancerous	CCLE	RRSPLDHLP	DEG_APCC_DBOX_1	16:24	Mutation altering degron motif	0.6583

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons