DegronMD

Uniprot ID: P52954

Source protein: Transcription factor LBX1

Source gene: LBX1

Class: DEG_APCC_DBOX_1

Location: 16:24

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9911

ASA_SCORE: 100.3889

COIL: 0.8379

CONS_SCORE: 0.5932

DSS_SCORE: 0.7837

HELIX: 0.1498

FCONS_SCORE: 1.1929

RIG_SCORE: 0.5977

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A27V	TCGA-BR-6452	STAD	TCGA	RRSPLDHLP	DEG_APCC_DBOX_1	0.25
p.A27V	DO38404	STAD	ICGC	RRSPLDHLP	DEG_APCC_DBOX_1	0.25
p.G12W	TCGA-G7-6795	KIRP	TCGA	RRSPLDHLP	DEG_APCC_DBOX_1	0.2222
p.G12W	DO20851	KIRP	ICGC	RRSPLDHLP	DEG_APCC_DBOX_1	0.2222
p.G7C	TCGA-K7-A5RF	LIHC	TCGA	RRSPLDHLP	DEG_APCC_DBOX_1	0.0833
p.G7C	DO52303	LIHC	ICGC	RRSPLDHLP	DEG_APCC_DBOX_1	0.0833
p.R17H	DO233245	GACA	ICGC	RRSPLDHLP	DEG_APCC_DBOX_1	0.8244
p.R16W	DO233709	GACA	ICGC	RRSPLDHLP	DEG_APCC_DBOX_1	0.7523
p.P25L	DO233838	GACA	ICGC	RRSPLDHLP	DEG_APCC_DBOX_1	0.3056
p.R17C	SIDM01088	Endometrial Carcinoma	GDSC	RRSPLDHLP	DEG_APCC_DBOX_1	0.8301
p.R17C	ACH-000965	Endometrial/Uterine Cancer	CCLE	RRSPLDHLP	DEG_APCC_DBOX_1	0.8301
p.S29P	ACH-001331	Head and Neck Cancer	CCLE	RRSPLDHLP	DEG_APCC_DBOX_1	0.1944
p.H22P	ACH-002267	Leukemia	CCLE	RRSPLDHLP	DEG_APCC_DBOX_1	0.6583
p.H22P	ACH-002360	Non-Cancerous	CCLE	RRSPLDHLP	DEG_APCC_DBOX_1	0.6583

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P52954	Transcription factor LBX1	DEG_APCC_DBOX_1	16:24	RRSPLDHLP	APC,CDC20,FZR1	0.9911	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons