DegronMD - P53539(FOSB)

FUNCTION: Heterodimerizes with proteins of the JUN family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to gene promoters containing an AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing their transcriptional activity (PubMed:12618758, PubMed:28981703). As part of the AP-1 complex, facilitates enhancer selection together with cell-type-specific transcription factors by collaboratively binding to nucleosomal enhancers and recruiting the SWI/SNF (BAF) chromatin remodeling complex to establish accessible chromatin (By similarity). Together with JUN, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (PubMed:12618758). Exhibits transactivation activity in vitro (By similarity). Involved in the display of nurturing behavior towards newborns (By similarity). May play a role in neurogenesis in the hippocampus and in learning and memory-related tasks by regulating the expression of various genes involved in neurogenesis, depression and epilepsy (By similarity). Implicated in behavioral responses related to morphine reward and spatial memory (By similarity). {ECO:0000250|UniProtKB:P13346, ECO:0000269|PubMed:12618758, ECO:0000269|PubMed:28981703}.; FUNCTION: [Isoform 11]: Exhibits lower transactivation activity than isoform 1 in vitro (By similarity). The heterodimer with JUN does not display any transcriptional activity, and may thereby act as an transcriptional inhibitor (By similarity). May be involved in the regulation of neurogenesis in the hippocampus (By similarity). May play a role in synaptic modifications in nucleus accumbens medium spiny neurons and thereby play a role in adaptive and pathological reward-dependent learning, including maladaptive responses involved in drug addiction (By similarity). Seems to be more stably expressed with a half-life of ~9.5 hours in cell culture as compared to 1.5 hours half-life of isoform 1 (By similarity). {ECO:0000250|UniProtKB:P13346}. View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R14Q	TCGA-AC-A8OS	BRCA	TCGA	DSGSRCS	DEG_SCF_TRCP1_1	10:16	Mutation altering degron motif	0.6218
p.R14Q	DO219599	BRCA	ICGC	DSGSRCS	DEG_SCF_TRCP1_1	10:16	Mutation altering degron motif	0.6218
p.R14Q	ACH-000194	Non-Cancerous	CCLE	DSGSRCS	DEG_SCF_TRCP1_1	10:16	Mutation altering degron motif	0.6218
p.S13F	TCGA-CV-6956	HNSC	TCGA	DSGSRCS	DEG_SCF_TRCP1_1	10:16	Mutation altering degron motif	0.7982
p.S13F	DO15815	HNSC	ICGC	DSGSRCS	DEG_SCF_TRCP1_1	10:16	Mutation altering degron motif	0.7982
p.S13F	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	DSGSRCS	DEG_SCF_TRCP1_1	10:16	Mutation altering degron motif	0.7982
p.S13F	ACH-000929	Lung Cancer	CCLE	DSGSRCS	DEG_SCF_TRCP1_1	10:16	Mutation altering degron motif	0.7982
p.S13F	NCI-H2110	lung	COSMIC	DSGSRCS	DEG_SCF_TRCP1_1	10:16	Mutation altering degron motif	0.7982
p.F2C	TCGA-FI-A2D5	UCEC	TCGA	DSGSRCS	DEG_SCF_TRCP1_1	10:16	Mutation blocking phosphorylation signal	0.5556
p.F2C	DO41331	UCEC	ICGC	DSGSRCS	DEG_SCF_TRCP1_1	10:16	Mutation blocking phosphorylation signal	0.5556
p.D8N	DO48370	BLCA	ICGC	DSGSRCS	DEG_SCF_TRCP1_1	10:16	Mutation rewiring degron network	0.2778
p.Q3E	DO233920	GACA	ICGC	DSGSRCS	DEG_SCF_TRCP1_1	10:16	Mutation blocking phosphorylation signal	0.5833
p.S11F	SIDM00778	Colorectal Carcinoma	GDSC	DSGSRCS	DEG_SCF_TRCP1_1	10:16	Mutation altering degron motif	0.9093
p.S11F	ACH-000403	Colon/Colorectal Cancer	CCLE	DSGSRCS	DEG_SCF_TRCP1_1	10:16	Mutation altering degron motif	0.9093
p.S11F	NCI-H747	large intestine	COSMIC	DSGSRCS	DEG_SCF_TRCP1_1	10:16	Mutation altering degron motif	0.9093

Kaplan plot for FOSB in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FOSB

UniProt ID: P53539

Entrez ID: 2354

Protein name: Protein FosB (FosB proto-oncogene, AP-1 transcription factor subunit) (G0/G1 switch regulatory protein 3) (Transcription factor AP-1 subunit FosB)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FOSB in