DegronMD

Uniprot ID: P53539

Source protein: Protein FosB

Source gene: FOSB

Class: DEG_SCF_TRCP1_1

Location: 10:16

E3 ligase: BTRC

DEGRON score: 0.997

ASA_SCORE: 60.8286

COIL: 0.835

CONS_SCORE: 0.5427

DSS_SCORE: 0.5018

HELIX: 0.112

FCONS_SCORE: 0.836

RIG_SCORE: 0.6293

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R14Q	TCGA-AC-A8OS	BRCA	TCGA	DSGSRCS	DEG_SCF_TRCP1_1	0.6218
p.R14Q	DO219599	BRCA	ICGC	DSGSRCS	DEG_SCF_TRCP1_1	0.6218
p.R14Q	ACH-000194	Non-Cancerous	CCLE	DSGSRCS	DEG_SCF_TRCP1_1	0.6218
p.S13F	TCGA-CV-6956	HNSC	TCGA	DSGSRCS	DEG_SCF_TRCP1_1	0.7982
p.S13F	DO15815	HNSC	ICGC	DSGSRCS	DEG_SCF_TRCP1_1	0.7982
p.S13F	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	DSGSRCS	DEG_SCF_TRCP1_1	0.7982
p.S13F	ACH-000929	Lung Cancer	CCLE	DSGSRCS	DEG_SCF_TRCP1_1	0.7982
p.S13F	NCI-H2110	lung	COSMIC	DSGSRCS	DEG_SCF_TRCP1_1	0.7982
p.F2C	TCGA-FI-A2D5	UCEC	TCGA	DSGSRCS	DEG_SCF_TRCP1_1	0.5556
p.F2C	DO41331	UCEC	ICGC	DSGSRCS	DEG_SCF_TRCP1_1	0.5556
p.D8N	DO48370	BLCA	ICGC	DSGSRCS	DEG_SCF_TRCP1_1	0.2778
p.Q3E	DO233920	GACA	ICGC	DSGSRCS	DEG_SCF_TRCP1_1	0.5833
p.S11F	SIDM00778	Colorectal Carcinoma	GDSC	DSGSRCS	DEG_SCF_TRCP1_1	0.9093
p.S11F	ACH-000403	Colon/Colorectal Cancer	CCLE	DSGSRCS	DEG_SCF_TRCP1_1	0.9093
p.S11F	NCI-H747	large_intestine	COSMIC	DSGSRCS	DEG_SCF_TRCP1_1	0.9093

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P53539	Protein FosB	DEG_SCF_TRCP1_1	10:16	DSGSRCS	BTRC	0.997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons