DegronMD - P53667(LIMK1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P276Q	TCGA-13-0765	OV	TCGA	PAYTPSGE	DEG_SCF_FBW7_2	276:283	Mutation altering degron motif	0.7035
p.R289Q	TCGA-A5-A0G1	UCEC	TCGA	PAYTPSGE	DEG_SCF_FBW7_2	276:283	Mutation rewiring degron network	0.1667
p.P276L	TCGA-AJ-A3BH	UCEC	TCGA	PAYTPSGE	DEG_SCF_FBW7_2	276:283	Mutation altering degron motif	0.6471
p.P276L	ACH-000820	Colon/Colorectal Cancer	CCLE	PAYTPSGE	DEG_SCF_FBW7_2	276:283	Mutation altering degron motif	0.6471
p.P280S	TCGA-CV-6961	HNSC	TCGA	PAYTPSGE	DEG_SCF_FBW7_2	276:283	Mutation altering degron motif	0.6752
p.R289W	TCGA-EC-A24G	UCEC	TCGA	PAYTPSGE	DEG_SCF_FBW7_2	276:283	Mutation rewiring degron network	0.1667
p.R286H	DO230311	COCA	ICGC	PAYTPSGE	DEG_SCF_FBW7_2	276:283	Mutation blocking phosphorylation signal	0.6944
p.V292A	DO234462	ESAD	ICGC	PAYTPSGE	DEG_SCF_FBW7_2	276:283	Mutation rewiring degron network	0.0833
p.V292I	DO233179	GACA	ICGC	PAYTPSGE	DEG_SCF_FBW7_2	276:283	Mutation rewiring degron network	0.0833
p.R281H	DO10880	GBM	ICGC	PAYTPSGE	DEG_SCF_FBW7_2	276:283	Mutation altering degron motif	0.8244
p.R281H	DO14186	HNSC	ICGC	PAYTPSGE	DEG_SCF_FBW7_2	276:283	Mutation altering degron motif	0.8244
p.S287C	DO14566	HNSC	ICGC	PAYTPSGE	DEG_SCF_FBW7_2	276:283	Mutation blocking phosphorylation signal	0.6667
p.T283I	DO222653	MELA	ICGC	PAYTPSGE	DEG_SCF_FBW7_2	276:283	Mutation altering degron motif	0.7078
p.R281C	DO232761	PBCA	ICGC	PAYTPSGE	DEG_SCF_FBW7_2	276:283	Mutation altering degron motif	0.8301
p.R286C	DO47299	SKCM	ICGC	PAYTPSGE	DEG_SCF_FBW7_2	276:283	Mutation blocking phosphorylation signal	0.6944
p.L266M	DO38135	SKCM	ICGC	PAYTPSGE	DEG_SCF_FBW7_2	276:283	Mutation rewiring degron network	0.0556
p.E288D	DO229257	THCA	ICGC	PAYTPSGE	DEG_SCF_FBW7_2	276:283	Mutation rewiring degron network	0.1944
p.R286L	DO229250	THCA	ICGC	PAYTPSGE	DEG_SCF_FBW7_2	276:283	Mutation blocking phosphorylation signal	0.6944
p.R286L	NCI-H650	lung	COSMIC	PAYTPSGE	DEG_SCF_FBW7_2	276:283	Mutation blocking phosphorylation signal	0.6944
p.L274P	DO41999	UCEC	ICGC	PAYTPSGE	DEG_SCF_FBW7_2	276:283	Mutation blocking phosphorylation signal	0.7222
p.S281N	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	PAYTPSGE	DEG_SCF_FBW7_2	276:283	Mutation altering degron motif	0.5958
p.S281N	NCI-H1155	lung	COSMIC	PAYTPSGE	DEG_SCF_FBW7_2	276:283	Mutation altering degron motif	0.5958
p.H289R	SNU-61	large intestine	COSMIC	PAYTPSGE	DEG_SCF_FBW7_2	276:283	Mutation rewiring degron network	0.1667

Kaplan plot for LIMK1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LIMK1

UniProt ID: P53667

Entrez ID: 3984

Protein name: LIM domain kinase 1 (LIMK-1) (EC 2.7.11.1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LIMK1 in