DegronMD

Uniprot ID: P53667

Source protein: LIM domain kinase 1

Source gene: LIMK1

Class: DEG_SCF_FBW7_2

Location: 276:283

E3 ligase: FBXW7

DEGRON score: 0.9949

ASA_SCORE: 74.6375

COIL: 0.8934

CONS_SCORE: 0.3432

DSS_SCORE: 0.6959

HELIX: 0.051

FCONS_SCORE: 1.027

RIG_SCORE: 0.5895

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P276Q	TCGA-13-0765	OV	TCGA	PAYTPSGE	DEG_SCF_FBW7_2	0.7035
p.R289Q	TCGA-A5-A0G1	UCEC	TCGA	PAYTPSGE	DEG_SCF_FBW7_2	0.1667
p.P276L	TCGA-AJ-A3BH	UCEC	TCGA	PAYTPSGE	DEG_SCF_FBW7_2	0.6471
p.P276L	ACH-000820	Colon/Colorectal Cancer	CCLE	PAYTPSGE	DEG_SCF_FBW7_2	0.6471
p.P280S	TCGA-CV-6961	HNSC	TCGA	PAYTPSGE	DEG_SCF_FBW7_2	0.6752
p.R289W	TCGA-EC-A24G	UCEC	TCGA	PAYTPSGE	DEG_SCF_FBW7_2	0.1667
p.R286H	DO230311	COCA	ICGC	PAYTPSGE	DEG_SCF_FBW7_2	0.6944
p.V292A	DO234462	ESAD	ICGC	PAYTPSGE	DEG_SCF_FBW7_2	0.0833
p.V292I	DO233179	GACA	ICGC	PAYTPSGE	DEG_SCF_FBW7_2	0.0833
p.R281H	DO10880	GBM	ICGC	PAYTPSGE	DEG_SCF_FBW7_2	0.8244
p.R281H	DO14186	HNSC	ICGC	PAYTPSGE	DEG_SCF_FBW7_2	0.8244
p.S287C	DO14566	HNSC	ICGC	PAYTPSGE	DEG_SCF_FBW7_2	0.6667
p.T283I	DO222653	MELA	ICGC	PAYTPSGE	DEG_SCF_FBW7_2	0.7078
p.R281C	DO232761	PBCA	ICGC	PAYTPSGE	DEG_SCF_FBW7_2	0.8301
p.R286C	DO47299	SKCM	ICGC	PAYTPSGE	DEG_SCF_FBW7_2	0.6944
p.L266M	DO38135	SKCM	ICGC	PAYTPSGE	DEG_SCF_FBW7_2	0.0556
p.E288D	DO229257	THCA	ICGC	PAYTPSGE	DEG_SCF_FBW7_2	0.1944
p.R286L	DO229250	THCA	ICGC	PAYTPSGE	DEG_SCF_FBW7_2	0.6944
p.R286L	NCI-H650	lung	COSMIC	PAYTPSGE	DEG_SCF_FBW7_2	0.6944
p.L274P	DO41999	UCEC	ICGC	PAYTPSGE	DEG_SCF_FBW7_2	0.7222
p.S281N	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	PAYTPSGE	DEG_SCF_FBW7_2	0.5958
p.S281N	NCI-H1155	lung	COSMIC	PAYTPSGE	DEG_SCF_FBW7_2	0.5958
p.H289R	SNU-61	large_intestine	COSMIC	PAYTPSGE	DEG_SCF_FBW7_2	0.1667

Drug responses associated with LIMK1 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00689	DLBC\|B_cell_lymphoma	p.T198P (No)	GDSC	LIMK1 inhibitor BMS4	72.4838
SIDM00678	BLCA\|bladder	p.K66T (No)	GDSC	LIMK1 inhibitor BMS4	440.2294
SIDM00778	COREAD\|large_intestine	p.K66T (No)	GDSC	LIMK1 inhibitor BMS4	489.8215
SIDM00749	LUAD\|lung_NSCLC_adenocarcinoma	p.T420S (No)	GDSC	LIMK1 inhibitor BMS4	311.4999
SIDM00829	LAML\|acute_myeloid_leukaemia	p.T606P (No)	GDSC	LIMK1 inhibitor BMS4	190.3977
SIDM00629	BRCA\|breast	p.L112F (No)	GDSC	LIMK1 inhibitor BMS4	83.247
SIDM00121	ALL\|lymphoblastic_leukemia	p.T606P (No)	GDSC	LIMK1 inhibitor BMS4	55.7728
SIDM00494	LUAD\|lung_NSCLC_adenocarcinoma	p.T606P (No)	GDSC	LIMK1 inhibitor BMS4	286.7664
SIDM00079	OV\|ovary	p.T606P (No)	GDSC	LIMK1 inhibitor BMS4	355.5732
SIDM00964	UNCLASSIFIED\|prostate	p.T606P (No)	GDSC	LIMK1 inhibitor BMS4	288.5914
SIDM00896	DLBC\|B_cell_lymphoma	p.W434* (No)	GDSC	LIMK1 inhibitor BMS4	130.3553
SIDM00818	KIRC\|kidney	p.T606P (No)	GDSC	LIMK1 inhibitor BMS4	94.5804
SIDM00045	STAD\|stomach	p.T606P (No)	GDSC	LIMK1 inhibitor BMS4	23.8536
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R200C (No)	GDSC	LIMK1 inhibitor BMS4	167.0764
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.S281N (Yes)	GDSC	LIMK1 inhibitor BMS4	167.0764
SIDM01007	ALL\|lymphoblastic_leukemia	p.R389* (No)	GDSC	LIMK1 inhibitor BMS4	72.8548
SIDM01007	ALL\|lymphoblastic_leukemia	p.R634H (No)	GDSC	LIMK1 inhibitor BMS4	72.8548
SIDM00664	PAAD\|pancreas	p.T606P (No)	GDSC	LIMK1 inhibitor BMS4	347.216
SIDM00381	CESC\|cervix	p.L26P (No)	GDSC	LIMK1 inhibitor BMS4	522.0258
SIDM00718	LUAD\|lung_NSCLC_adenocarcinoma	p.D531Y (No)	GDSC	LIMK1 inhibitor BMS4	89.9884
SIDM00415	UNCLASSIFIED\|B_cell_leukemia	p.T606P (No)	GDSC	LIMK1 inhibitor BMS4	518.9072
SIDM00498	COREAD\|large_intestine	p.R389* (No)	GDSC	LIMK1 inhibitor BMS4	96.9079
SIDM00756	LUAD\|lung_NSCLC_adenocarcinoma	p.E528K (No)	GDSC	LIMK1 inhibitor BMS4	204.3849
SIDM01237	LIHC\|liver	p.G480R (No)	GDSC	LIMK1 inhibitor BMS4	311.2393
SIDM00194	COREAD\|large_intestine	p.H259R (No)	GDSC	LIMK1 inhibitor BMS4	1209.796
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.R389* (No)	GDSC	LIMK1 inhibitor BMS4	164.2816
SIDM00504	LGG\|glioma	p.T606P (No)	GDSC	LIMK1 inhibitor BMS4	173.6577
SIDM00156	NB\|neuroblastoma	p.R585H (No)	GDSC	LIMK1 inhibitor BMS4	150.0019
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.P577S (No)	GDSC	LIMK1 inhibitor BMS4	23.1526
SIDM00999	BLCA\|bladder	p.R483H (No)	GDSC	LIMK1 inhibitor BMS4	113.4233
SIDM00217	COREAD\|large_intestine	p.R506C (No)	GDSC	LIMK1 inhibitor BMS4	550.073
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.V14I (No)	GDSC	LIMK1 inhibitor BMS4	263.5545
SIDM00839	COREAD\|large_intestine	p.R634H (No)	GDSC	LIMK1 inhibitor BMS4	196.0816
SIDM00699	SCLC\|lung_small_cell_carcinoma	p.T606P (No)	GDSC	LIMK1 inhibitor BMS4	99.3305
SIDM00699	SCLC\|lung_small_cell_carcinoma	p.H610P (No)	GDSC	LIMK1 inhibitor BMS4	99.3305
SIDM01159	UNCLASSIFIED\|soft_tissue_other	p.T606P (No)	GDSC	LIMK1 inhibitor BMS4	41.1384
SIDM00125	KIRC\|kidney	p.H610P (No)	GDSC	LIMK1 inhibitor BMS4	72.4195
SIDM00987	THCA\|thyroid	p.T606P (No)	GDSC	LIMK1 inhibitor BMS4	22.5034
SIDM00458	LAML\|acute_myeloid_leukaemia	p.H610P (No)	GDSC	LIMK1 inhibitor BMS4	65.8588
SIDM01090	COREAD\|large_intestine	p.L273fs*1 (Yes)	GDSC	LIMK1 inhibitor BMS4	49.7713
SIDM00427	UNCLASSIFIED\|rhabdomyosarcoma	p.T606P (No)	GDSC	LIMK1 inhibitor BMS4	37.2862
SIDM01169	OV\|ovary	p.T606P (No)	GDSC	LIMK1 inhibitor BMS4	179.5615
SIDM00120	PRAD\|prostate	p.T606P (No)	GDSC	LIMK1 inhibitor BMS4	77.9012
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.S439G (No)	GDSC	LIMK1 inhibitor BMS4	118.6861
SIDM00895	DLBC\|B_cell_lymphoma	p.K66T (No)	GDSC	LIMK1 inhibitor BMS4	142.2063
SIDM01060	SKCM\|melanoma	p.S534F (No)	GDSC	LIMK1 inhibitor BMS4	21.706
SIDM00419	UNCLASSIFIED\|ewings_sarcoma	p.T606P (No)	GDSC	LIMK1 inhibitor BMS4	132.9928
SIDM00983	BLCA\|bladder	p.G613A (No)	GDSC	LIMK1 inhibitor BMS4	49.4393
SIDM00654	SCLC\|lung_small_cell_carcinoma	p.R248H (No)	GDSC	LIMK1 inhibitor BMS4	83.3533
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.R320L (No)	GDSC	LIMK1 inhibitor BMS4	53.1014
SIDM01170	OV\|ovary	p.R9I (No)	GDSC	LIMK1 inhibitor BMS4	150.0867
SIDM00277	UNCLASSIFIED\|haematopoietic_neoplasm_other	p.T606P (No)	GDSC	LIMK1 inhibitor BMS4	21.7733
SIDM00857	SKCM\|melanoma	p.P576L (No)	GDSC	LIMK1 inhibitor BMS4	74.7954
SIDM00900	MM\|myeloma	p.K66T (No)	GDSC	LIMK1 inhibitor BMS4	199.895

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PAYTPSGE

Degron related mutations and impact score

Drug responses associated with LIMK1 mutations

All proteins holding degron of PAYTPSGE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P53667	LIM domain kinase 1	DEG_SCF_FBW7_2	276:283	PAYTPSGE	FBXW7	0.9949	More...