DegronMD

Uniprot ID: P53667

Source protein: LIM domain kinase 1

Source gene: LIMK1

Class: DEG_SCF_FBW7_2

Location: 276:283

E3 ligase: FBXW7

DEGRON score: 0.9949

ASA_SCORE: 74.6375

COIL: 0.8934

CONS_SCORE: 0.3432

DSS_SCORE: 0.6959

HELIX: 0.051

FCONS_SCORE: 1.027

RIG_SCORE: 0.5895

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R281C	DO232761	PBCA	ICGC	PAYTPSGE	DEG_SCF_FBW7_2	0.8301
p.R281H	DO10880	GBM	ICGC	PAYTPSGE	DEG_SCF_FBW7_2	0.8244
p.R281H	DO14186	HNSC	ICGC	PAYTPSGE	DEG_SCF_FBW7_2	0.8244
p.L274P	DO41999	UCEC	ICGC	PAYTPSGE	DEG_SCF_FBW7_2	0.7222
p.T283I	DO222653	MELA	ICGC	PAYTPSGE	DEG_SCF_FBW7_2	0.7078
p.P276Q	TCGA-13-0765	OV	TCGA	PAYTPSGE	DEG_SCF_FBW7_2	0.7035
p.R286H	DO230311	COCA	ICGC	PAYTPSGE	DEG_SCF_FBW7_2	0.6944
p.R286C	DO47299	SKCM	ICGC	PAYTPSGE	DEG_SCF_FBW7_2	0.6944
p.R286L	DO229250	THCA	ICGC	PAYTPSGE	DEG_SCF_FBW7_2	0.6944
p.R286L	NCI-H650	lung	COSMIC	PAYTPSGE	DEG_SCF_FBW7_2	0.6944
p.P280S	TCGA-CV-6961	HNSC	TCGA	PAYTPSGE	DEG_SCF_FBW7_2	0.6752
p.S287C	DO14566	HNSC	ICGC	PAYTPSGE	DEG_SCF_FBW7_2	0.6667
p.P276L	TCGA-AJ-A3BH	UCEC	TCGA	PAYTPSGE	DEG_SCF_FBW7_2	0.6471
p.P276L	ACH-000820	Colon/Colorectal Cancer	CCLE	PAYTPSGE	DEG_SCF_FBW7_2	0.6471
p.S281N	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	PAYTPSGE	DEG_SCF_FBW7_2	0.5958
p.S281N	NCI-H1155	lung	COSMIC	PAYTPSGE	DEG_SCF_FBW7_2	0.5958
p.E288D	DO229257	THCA	ICGC	PAYTPSGE	DEG_SCF_FBW7_2	0.1944
p.R289Q	TCGA-A5-A0G1	UCEC	TCGA	PAYTPSGE	DEG_SCF_FBW7_2	0.1667
p.R289W	TCGA-EC-A24G	UCEC	TCGA	PAYTPSGE	DEG_SCF_FBW7_2	0.1667
p.H289R	SNU-61	large_intestine	COSMIC	PAYTPSGE	DEG_SCF_FBW7_2	0.1667
p.V292A	DO234462	ESAD	ICGC	PAYTPSGE	DEG_SCF_FBW7_2	0.0833
p.V292I	DO233179	GACA	ICGC	PAYTPSGE	DEG_SCF_FBW7_2	0.0833
p.L266M	DO38135	SKCM	ICGC	PAYTPSGE	DEG_SCF_FBW7_2	0.0556

Showing 1 to 23 of 23 entries

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Drug responses associated with LIMK1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00121	ALL\|lymphoblastic_leukemia	p.T606P (No)	GDSC	LIMK1 inhibitor BMS4	55.7728
SIDM01007	ALL\|lymphoblastic_leukemia	p.R389* (No)	GDSC	LIMK1 inhibitor BMS4	72.8548
SIDM01007	ALL\|lymphoblastic_leukemia	p.R634H (No)	GDSC	LIMK1 inhibitor BMS4	72.8548
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.S439G (No)	GDSC	LIMK1 inhibitor BMS4	118.6861
SIDM00678	BLCA\|bladder	p.K66T (No)	GDSC	LIMK1 inhibitor BMS4	440.2294
SIDM00999	BLCA\|bladder	p.R483H (No)	GDSC	LIMK1 inhibitor BMS4	113.4233
SIDM00983	BLCA\|bladder	p.G613A (No)	GDSC	LIMK1 inhibitor BMS4	49.4393
SIDM00629	BRCA\|breast	p.L112F (No)	GDSC	LIMK1 inhibitor BMS4	83.247
SIDM00381	CESC\|cervix	p.L26P (No)	GDSC	LIMK1 inhibitor BMS4	522.0258
SIDM00778	COREAD\|large_intestine	p.K66T (No)	GDSC	LIMK1 inhibitor BMS4	489.8215
SIDM00498	COREAD\|large_intestine	p.R389* (No)	GDSC	LIMK1 inhibitor BMS4	96.9079
SIDM00194	COREAD\|large_intestine	p.H259R (No)	GDSC	LIMK1 inhibitor BMS4	1209.796
SIDM00217	COREAD\|large_intestine	p.R506C (No)	GDSC	LIMK1 inhibitor BMS4	550.073
SIDM00839	COREAD\|large_intestine	p.R634H (No)	GDSC	LIMK1 inhibitor BMS4	196.0816
SIDM01090	COREAD\|large_intestine	p.L273fs*1 (Yes)	GDSC	LIMK1 inhibitor BMS4	49.7713
SIDM00689	DLBC\|B_cell_lymphoma	p.T198P (No)	GDSC	LIMK1 inhibitor BMS4	72.4838
SIDM00896	DLBC\|B_cell_lymphoma	p.W434* (No)	GDSC	LIMK1 inhibitor BMS4	130.3553
SIDM00895	DLBC\|B_cell_lymphoma	p.K66T (No)	GDSC	LIMK1 inhibitor BMS4	142.2063
SIDM00818	KIRC\|kidney	p.T606P (No)	GDSC	LIMK1 inhibitor BMS4	94.5804
SIDM00125	KIRC\|kidney	p.H610P (No)	GDSC	LIMK1 inhibitor BMS4	72.4195
SIDM00829	LAML\|acute_myeloid_leukaemia	p.T606P (No)	GDSC	LIMK1 inhibitor BMS4	190.3977
SIDM00458	LAML\|acute_myeloid_leukaemia	p.H610P (No)	GDSC	LIMK1 inhibitor BMS4	65.8588
SIDM00504	LGG\|glioma	p.T606P (No)	GDSC	LIMK1 inhibitor BMS4	173.6577
SIDM01237	LIHC\|liver	p.G480R (No)	GDSC	LIMK1 inhibitor BMS4	311.2393
SIDM00749	LUAD\|lung_NSCLC_adenocarcinoma	p.T420S (No)	GDSC	LIMK1 inhibitor BMS4	311.4999

Showing 1 to 25 of 54 entries

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All proteins holding degron of PAYTPSGE

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P53667	LIM domain kinase 1	DEG_SCF_FBW7_2	276:283	PAYTPSGE	FBXW7	0.9949	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PAYTPSGE

Degron related mutations and impact score

Drug responses associated with LIMK1 mutations

All proteins holding degron of PAYTPSGE