DegronMD - P53708(ITGA8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P649L	TCGA-16-0849	GBM	TCGA	EDNLCVPDL	DEG_COP1_1	643:651	Mutation altering degron motif	0.7582
p.P649L	DO13917	GBM	ICGC	EDNLCVPDL	DEG_COP1_1	643:651	Mutation altering degron motif	0.7582
p.P649S	TCGA-16-0849	GBM	TCGA	EDNLCVPDL	DEG_COP1_1	643:651	Mutation altering degron motif	0.6752
p.P649S	TCGA-EE-A29E	SKCM	TCGA	EDNLCVPDL	DEG_COP1_1	643:651	Mutation altering degron motif	0.6752
p.P649S	DO13917	GBM	ICGC	EDNLCVPDL	DEG_COP1_1	643:651	Mutation altering degron motif	0.6752
p.P649S	DO37831	SKCM	ICGC	EDNLCVPDL	DEG_COP1_1	643:651	Mutation altering degron motif	0.6752
p.V648F	TCGA-22-5472	LUSC	TCGA	EDNLCVPDL	DEG_COP1_1	643:651	Mutation altering degron motif	0.7068
p.V648F	DO27421	LUSC	ICGC	EDNLCVPDL	DEG_COP1_1	643:651	Mutation altering degron motif	0.7068
p.S654L	TCGA-36-2533	OV	TCGA	EDNLCVPDL	DEG_COP1_1	643:651	Mutation rewiring degron network	0.25
p.S654L	TCGA-P3-A6T3	HNSC	TCGA	EDNLCVPDL	DEG_COP1_1	643:651	Mutation rewiring degron network	0.25
p.S654L	DO49055	HNSC	ICGC	EDNLCVPDL	DEG_COP1_1	643:651	Mutation rewiring degron network	0.25
p.S654L	DO32516	OV	ICGC	EDNLCVPDL	DEG_COP1_1	643:651	Mutation rewiring degron network	0.25
p.D650Y	TCGA-95-7039	LUAD	TCGA	EDNLCVPDL	DEG_COP1_1	643:651	Mutation altering degron motif	0.7325
p.D650Y	TCGA-AC-A23H	BRCA	TCGA	EDNLCVPDL	DEG_COP1_1	643:651	Mutation altering degron motif	0.7325
p.D650Y	DO2401	BRCA	ICGC	EDNLCVPDL	DEG_COP1_1	643:651	Mutation altering degron motif	0.7325
p.D650Y	DO23907	LUAD	ICGC	EDNLCVPDL	DEG_COP1_1	643:651	Mutation altering degron motif	0.7325
p.P649T	TCGA-CR-7389	HNSC	TCGA	EDNLCVPDL	DEG_COP1_1	643:651	Mutation altering degron motif	0.7031
p.P649T	DO14190	HNSC	ICGC	EDNLCVPDL	DEG_COP1_1	643:651	Mutation altering degron motif	0.7031
p.P657Q	TCGA-D3-A2JP	SKCM	TCGA	EDNLCVPDL	DEG_COP1_1	643:651	Mutation rewiring degron network	0.1667
p.P657Q	DO47407	SKCM	ICGC	EDNLCVPDL	DEG_COP1_1	643:651	Mutation rewiring degron network	0.1667
p.Q661H	TCGA-FS-A1ZR	SKCM	TCGA	EDNLCVPDL	DEG_COP1_1	643:651	Mutation rewiring degron network	0.0556
p.Q661H	DO37651	SKCM	ICGC	EDNLCVPDL	DEG_COP1_1	643:651	Mutation rewiring degron network	0.0556
p.H636Q	DO228974	LICA	ICGC	EDNLCVPDL	DEG_COP1_1	643:651	Mutation rewiring degron network	0.1389
p.H636Q	DO231018	LUSC	ICGC	EDNLCVPDL	DEG_COP1_1	643:651	Mutation rewiring degron network	0.1389
p.L646M	DO229036	LICA	ICGC	EDNLCVPDL	DEG_COP1_1	643:651	Mutation altering degron motif	0.5999
p.A655V	SIDM00373	Endometrial Carcinoma	GDSC	EDNLCVPDL	DEG_COP1_1	643:651	Mutation rewiring degron network	0.2222
p.A655V	ACH-000974	Endometrial/Uterine Cancer	CCLE	EDNLCVPDL	DEG_COP1_1	643:651	Mutation rewiring degron network	0.2222
p.N645K	SIDM00282	Colorectal Carcinoma	GDSC	EDNLCVPDL	DEG_COP1_1	643:651	Mutation altering degron motif	0.5806
p.N645K	ACH-000998	Colon/Colorectal Cancer	CCLE	EDNLCVPDL	DEG_COP1_1	643:651	Mutation altering degron motif	0.5806
p.N645K	CW-2	large intestine	COSMIC	EDNLCVPDL	DEG_COP1_1	643:651	Mutation altering degron motif	0.5806
p.V648A	SIDM00276	Biliary Tract Carcinoma	GDSC	EDNLCVPDL	DEG_COP1_1	643:651	Mutation altering degron motif	0.6936
p.V648A	ACH-001858	Bile Duct Cancer	CCLE	EDNLCVPDL	DEG_COP1_1	643:651	Mutation altering degron motif	0.6936
p.V648A	ACH-002237	Bile Duct Cancer	CCLE	EDNLCVPDL	DEG_COP1_1	643:651	Mutation altering degron motif	0.6936
p.V648A	ETK-1	biliary tract	COSMIC	EDNLCVPDL	DEG_COP1_1	643:651	Mutation altering degron motif	0.6936

Kaplan plot for ITGA8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ITGA8

UniProt ID: P53708

Entrez ID: 8516

Protein name: Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ITGA8 in