DegronMD

Uniprot ID: P53708

Source protein: Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain]

Source gene: ITGA8

Class: DEG_COP1_1

Location: 643:651

E3 ligase: COP1

DEGRON score: 0.6027

ASA_SCORE: 54.3778

COIL: 0.5781

CONS_SCORE: 0.5971

DSS_SCORE: 0.1444

HELIX: 0.0951

FCONS_SCORE: 1.3421

RIG_SCORE: 0.847

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P649L	TCGA-16-0849	GBM	TCGA	EDNLCVPDL	DEG_COP1_1	0.7582
p.P649L	DO13917	GBM	ICGC	EDNLCVPDL	DEG_COP1_1	0.7582
p.P649S	TCGA-16-0849	GBM	TCGA	EDNLCVPDL	DEG_COP1_1	0.6752
p.P649S	TCGA-EE-A29E	SKCM	TCGA	EDNLCVPDL	DEG_COP1_1	0.6752
p.P649S	DO13917	GBM	ICGC	EDNLCVPDL	DEG_COP1_1	0.6752
p.P649S	DO37831	SKCM	ICGC	EDNLCVPDL	DEG_COP1_1	0.6752
p.V648F	TCGA-22-5472	LUSC	TCGA	EDNLCVPDL	DEG_COP1_1	0.7068
p.V648F	DO27421	LUSC	ICGC	EDNLCVPDL	DEG_COP1_1	0.7068
p.S654L	TCGA-36-2533	OV	TCGA	EDNLCVPDL	DEG_COP1_1	0.25
p.S654L	TCGA-P3-A6T3	HNSC	TCGA	EDNLCVPDL	DEG_COP1_1	0.25
p.S654L	DO49055	HNSC	ICGC	EDNLCVPDL	DEG_COP1_1	0.25
p.S654L	DO32516	OV	ICGC	EDNLCVPDL	DEG_COP1_1	0.25
p.D650Y	TCGA-95-7039	LUAD	TCGA	EDNLCVPDL	DEG_COP1_1	0.7325
p.D650Y	TCGA-AC-A23H	BRCA	TCGA	EDNLCVPDL	DEG_COP1_1	0.7325
p.D650Y	DO2401	BRCA	ICGC	EDNLCVPDL	DEG_COP1_1	0.7325
p.D650Y	DO23907	LUAD	ICGC	EDNLCVPDL	DEG_COP1_1	0.7325
p.P649T	TCGA-CR-7389	HNSC	TCGA	EDNLCVPDL	DEG_COP1_1	0.7031
p.P649T	DO14190	HNSC	ICGC	EDNLCVPDL	DEG_COP1_1	0.7031
p.P657Q	TCGA-D3-A2JP	SKCM	TCGA	EDNLCVPDL	DEG_COP1_1	0.1667
p.P657Q	DO47407	SKCM	ICGC	EDNLCVPDL	DEG_COP1_1	0.1667
p.Q661H	TCGA-FS-A1ZR	SKCM	TCGA	EDNLCVPDL	DEG_COP1_1	0.0556
p.Q661H	DO37651	SKCM	ICGC	EDNLCVPDL	DEG_COP1_1	0.0556
p.H636Q	DO228974	LICA	ICGC	EDNLCVPDL	DEG_COP1_1	0.1389
p.H636Q	DO231018	LUSC	ICGC	EDNLCVPDL	DEG_COP1_1	0.1389
p.L646M	DO229036	LICA	ICGC	EDNLCVPDL	DEG_COP1_1	0.5999
p.A655V	SIDM00373	Endometrial Carcinoma	GDSC	EDNLCVPDL	DEG_COP1_1	0.2222
p.A655V	ACH-000974	Endometrial/Uterine Cancer	CCLE	EDNLCVPDL	DEG_COP1_1	0.2222
p.N645K	SIDM00282	Colorectal Carcinoma	GDSC	EDNLCVPDL	DEG_COP1_1	0.5806
p.N645K	ACH-000998	Colon/Colorectal Cancer	CCLE	EDNLCVPDL	DEG_COP1_1	0.5806
p.N645K	CW-2	large_intestine	COSMIC	EDNLCVPDL	DEG_COP1_1	0.5806
p.V648A	SIDM00276	Biliary Tract Carcinoma	GDSC	EDNLCVPDL	DEG_COP1_1	0.6936
p.V648A	ACH-001858	Bile Duct Cancer	CCLE	EDNLCVPDL	DEG_COP1_1	0.6936
p.V648A	ACH-002237	Bile Duct Cancer	CCLE	EDNLCVPDL	DEG_COP1_1	0.6936
p.V648A	ETK-1	biliary_tract	COSMIC	EDNLCVPDL	DEG_COP1_1	0.6936

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: EDNLCVPDL

Degron related mutations and impact score

Drug responses associated with ITGA8 mutations

All proteins holding degron of EDNLCVPDL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P53708	Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain]	DEG_COP1_1	643:651	EDNLCVPDL	COP1	0.6027	More...