DegronMD - P53805(RCAN1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S167Y	TCGA-19-5956	GBM	TCGA	LAPPNPDKQFLI	DEG_ODPH_VHL_1	151:162	Mutation blocking phosphorylation signal	0.6389
p.A152S	TCGA-66-2763	LUSC	TCGA	LAPPNPDKQFLI	DEG_ODPH_VHL_1	151:162	Mutation altering degron motif	0.7588
p.L161Q	TCGA-A3-3346	KIRC	TCGA	LAPPNPDKQFLI	DEG_ODPH_VHL_1	151:162	Mutation altering degron motif	0.6654
p.H150Y	TCGA-PG-A917	UCEC	TCGA	LAPPNPDKQFLI	DEG_ODPH_VHL_1	151:162	Mutation rewiring degron network	0.3056
p.P168T	DO229045	LICA	ICGC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	151:162	Mutation rewiring degron network	0.1667
p.R161G	DO231007	LUSC	ICGC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	151:162	Mutation altering degron motif	0.7568
p.E153V	DO232861	NACA	ICGC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	151:162	Mutation altering degron motif	0.7693
p.P158S	DO28015	OV	ICGC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	151:162	Mutation altering degron motif	0.6752
p.P158S	ACH-001551	Skin Cancer	CCLE	LAPPNPDKQFLI	DEG_ODPH_VHL_1	151:162	Mutation altering degron motif	0.6752
p.K153E	SIDM00649	Non-Small Cell Lung Carcinoma	GDSC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	151:162	Mutation altering degron motif	0.7022
p.R146Q	SIDM00202	Ewing's Sarcoma	GDSC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	151:162	Mutation rewiring degron network	0.1944
p.R146Q	EW-3	bone	COSMIC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	151:162	Mutation rewiring degron network	0.1944
p.P145R	SIDM00879	Breast Carcinoma	GDSC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	151:162	Mutation rewiring degron network	0.1667
p.P145R	HCC1500	breast	COSMIC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	151:162	Mutation rewiring degron network	0.1667
p.V147A	SIDM00217	Colorectal Carcinoma	GDSC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	151:162	Mutation rewiring degron network	0.2222
p.V147A	SNU-1040	large intestine	COSMIC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	151:162	Mutation rewiring degron network	0.2222
p.I171V	SIDM00217	Colorectal Carcinoma	GDSC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	151:162	Mutation rewiring degron network	0.0833
p.I171V	SNU-1040	large intestine	COSMIC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	151:162	Mutation rewiring degron network	0.0833
p.R146W	SIDM00808	Burkitt's Lymphoma	GDSC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	151:162	Mutation rewiring degron network	0.1944
p.R146W	SIDM01254	Burkitt's Lymphoma	GDSC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	151:162	Mutation rewiring degron network	0.1944
p.A144T	SIDM01617	Endometrial Carcinoma	GDSC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	151:162	Mutation rewiring degron network	0.1389
p.S153C	ACH-000865	Esophageal Cancer	CCLE	LAPPNPDKQFLI	DEG_ODPH_VHL_1	151:162	Mutation altering degron motif	0.7541
p.S153C	KYSE-450	oesophagus	COSMIC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	151:162	Mutation altering degron motif	0.7541
p.A168V	ACH-000941	Endometrial/Uterine Cancer	CCLE	LAPPNPDKQFLI	DEG_ODPH_VHL_1	151:162	Mutation rewiring degron network	0.1667
p.A168V	ACH-000954	Endometrial/Uterine Cancer	CCLE	LAPPNPDKQFLI	DEG_ODPH_VHL_1	151:162	Mutation rewiring degron network	0.1667
p.A168V	ACH-000999	Colon/Colorectal Cancer	CCLE	LAPPNPDKQFLI	DEG_ODPH_VHL_1	151:162	Mutation rewiring degron network	0.1667
p.A168V	ACH-001517	Endometrial/Uterine Cancer	CCLE	LAPPNPDKQFLI	DEG_ODPH_VHL_1	151:162	Mutation rewiring degron network	0.1667
p.A168V	HEC-1	endometrium	COSMIC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	151:162	Mutation rewiring degron network	0.1667
p.A168V	SNU-1040	large intestine	COSMIC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	151:162	Mutation rewiring degron network	0.1667
p.R162K	NCI-H2009	lung	COSMIC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	151:162	Mutation altering degron motif	0.7237
p.T166M	C2BBe1	large intestine	COSMIC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	151:162	Mutation rewiring degron network	0.2222
p.T160S	PF-382	haematopoietic and lymphoid tissue	COSMIC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	151:162	Mutation altering degron motif	0.7116
p.I146V	SNU-1040	large intestine	COSMIC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	151:162	Mutation rewiring degron network	0.1944
p.S163C	KYSE-450	oesophagus	COSMIC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	151:162	Mutation blocking phosphorylation signal	0.75

Kaplan plot for RCAN1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RCAN1

UniProt ID: P53805

Entrez ID: 1827

Protein name: Calcipressin-1 (Adapt78) (Down syndrome critical region protein 1) (Myocyte-enriched calcineurin-interacting protein 1) (MCIP1) (Regulator of calcineurin 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RCAN1 in