DegronMD

Uniprot ID: P53805

Source protein: Calcipressin-1

Source gene: RCAN1

Class: DEG_ODPH_VHL_1

Location: 151:162

E3 ligase: VHL

DEGRON score: 0.6917

ASA_SCORE: 68.55

COIL: 0.709

CONS_SCORE: 0.7801

DSS_SCORE: 0.5084

HELIX: 0.1461

FCONS_SCORE: 1.0865

RIG_SCORE: 0.682

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S167Y	TCGA-19-5956	GBM	TCGA	LAPPNPDKQFLI	DEG_ODPH_VHL_1	0.6389
p.A152S	TCGA-66-2763	LUSC	TCGA	LAPPNPDKQFLI	DEG_ODPH_VHL_1	0.7588
p.L161Q	TCGA-A3-3346	KIRC	TCGA	LAPPNPDKQFLI	DEG_ODPH_VHL_1	0.6654
p.H150Y	TCGA-PG-A917	UCEC	TCGA	LAPPNPDKQFLI	DEG_ODPH_VHL_1	0.3056
p.P168T	DO229045	LICA	ICGC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	0.1667
p.R161G	DO231007	LUSC	ICGC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	0.7568
p.E153V	DO232861	NACA	ICGC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	0.7693
p.P158S	DO28015	OV	ICGC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	0.6752
p.P158S	ACH-001551	Skin Cancer	CCLE	LAPPNPDKQFLI	DEG_ODPH_VHL_1	0.6752
p.K153E	SIDM00649	Non-Small Cell Lung Carcinoma	GDSC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	0.7022
p.R146Q	SIDM00202	Ewing's Sarcoma	GDSC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	0.1944
p.R146Q	EW-3	bone	COSMIC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	0.1944
p.P145R	SIDM00879	Breast Carcinoma	GDSC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	0.1667
p.P145R	HCC1500	breast	COSMIC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	0.1667
p.V147A	SIDM00217	Colorectal Carcinoma	GDSC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	0.2222
p.V147A	SNU-1040	large_intestine	COSMIC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	0.2222
p.I171V	SIDM00217	Colorectal Carcinoma	GDSC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	0.0833
p.I171V	SNU-1040	large_intestine	COSMIC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	0.0833
p.R146W	SIDM00808	Burkitt's Lymphoma	GDSC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	0.1944
p.R146W	SIDM01254	Burkitt's Lymphoma	GDSC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	0.1944
p.A144T	SIDM01617	Endometrial Carcinoma	GDSC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	0.1389
p.S153C	ACH-000865	Esophageal Cancer	CCLE	LAPPNPDKQFLI	DEG_ODPH_VHL_1	0.7541
p.S153C	KYSE-450	oesophagus	COSMIC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	0.7541
p.A168V	ACH-000941	Endometrial/Uterine Cancer	CCLE	LAPPNPDKQFLI	DEG_ODPH_VHL_1	0.1667
p.A168V	ACH-000954	Endometrial/Uterine Cancer	CCLE	LAPPNPDKQFLI	DEG_ODPH_VHL_1	0.1667
p.A168V	ACH-000999	Colon/Colorectal Cancer	CCLE	LAPPNPDKQFLI	DEG_ODPH_VHL_1	0.1667
p.A168V	ACH-001517	Endometrial/Uterine Cancer	CCLE	LAPPNPDKQFLI	DEG_ODPH_VHL_1	0.1667
p.A168V	HEC-1	endometrium	COSMIC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	0.1667
p.A168V	SNU-1040	large_intestine	COSMIC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	0.1667
p.R162K	NCI-H2009	lung	COSMIC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	0.7237
p.T166M	C2BBe1	large_intestine	COSMIC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	0.2222
p.T160S	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	0.7116
p.I146V	SNU-1040	large_intestine	COSMIC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	0.1944
p.S163C	KYSE-450	oesophagus	COSMIC	LAPPNPDKQFLI	DEG_ODPH_VHL_1	0.75

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPPNPDKQFLI

Degron related mutations and impact score

Drug responses associated with RCAN1 mutations

All proteins holding degron of LAPPNPDKQFLI

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P53805	Calcipressin-1	DEG_ODPH_VHL_1	151:162	LAPPNPDKQFLI	VHL	0.6917	More...