DegronMD - P54274(TERF1)

TERF1

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R356G	TCGA-17-Z058	LUAD	TCGA	VGTPQST	DEG_SCF_FBW7_1	342:348	Mutation rewiring degron network	0.1111
p.P345H	TCGA-EE-A183	SKCM	TCGA	VGTPQST	DEG_SCF_FBW7_1	342:348	Mutation altering degron motif	0.7694
p.D334N	TCGA-F5-6814	READ	TCGA	VGTPQST	DEG_SCF_FBW7_1	342:348	Mutation rewiring degron network	0.1111
p.V344F	DO228948	LICA	ICGC	VGTPQST	DEG_SCF_FBW7_1	342:348	Mutation altering degron motif	0.7068
p.S334I	DO229015	LICA	ICGC	VGTPQST	DEG_SCF_FBW7_1	342:348	Mutation rewiring degron network	0.1111
p.S334I	DO229024	LICA	ICGC	VGTPQST	DEG_SCF_FBW7_1	342:348	Mutation rewiring degron network	0.1111
p.P352H	DO26552	LUSC	ICGC	VGTPQST	DEG_SCF_FBW7_1	342:348	Mutation substituting flanking lysine	0.3333
p.I342M	DO50118	STAD	ICGC	VGTPQST	DEG_SCF_FBW7_1	342:348	Mutation altering degron motif	0.7618
p.P343A	DO229213	THCA	ICGC	VGTPQST	DEG_SCF_FBW7_1	342:348	Mutation altering degron motif	0.7503
p.P349S	DO42177	UCEC	ICGC	VGTPQST	DEG_SCF_FBW7_1	342:348	Mutation rewiring degron network	0.3056
p.N336H	SIDM00537	Colorectal Carcinoma	GDSC	VGTPQST	DEG_SCF_FBW7_1	342:348	Mutation rewiring degron network	0.1667
p.N336H	ACH-001345	Colon/Colorectal Cancer	CCLE	VGTPQST	DEG_SCF_FBW7_1	342:348	Mutation rewiring degron network	0.1667
p.N336H	GP5d	large intestine	COSMIC	VGTPQST	DEG_SCF_FBW7_1	342:348	Mutation rewiring degron network	0.1667
p.D334E	SIDM00863	Burkitt's Lymphoma	GDSC	VGTPQST	DEG_SCF_FBW7_1	342:348	Mutation rewiring degron network	0.1111

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*NOTE: the Kaplan plots were collected from OncoLnc