DegronMD

Uniprot ID: P54274

Source protein: Telomeric repeat-binding factor 1

Source gene: TERF1

Class: DEG_SCF_FBW7_1

Location: 342:348

E3 ligase: FBXW7

DEGRON score: 0.994

ASA_SCORE: 79.9857

COIL: 0.8153

CONS_SCORE: 0.3735

DSS_SCORE: 0.7692

HELIX: 0.1661

FCONS_SCORE: 0.996

RIG_SCORE: 0.629

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R356G	TCGA-17-Z058	LUAD	TCGA	VGTPQST	DEG_SCF_FBW7_1	0.1111
p.P345H	TCGA-EE-A183	SKCM	TCGA	VGTPQST	DEG_SCF_FBW7_1	0.7694
p.D334N	TCGA-F5-6814	READ	TCGA	VGTPQST	DEG_SCF_FBW7_1	0.1111
p.V344F	DO228948	LICA	ICGC	VGTPQST	DEG_SCF_FBW7_1	0.7068
p.S334I	DO229015	LICA	ICGC	VGTPQST	DEG_SCF_FBW7_1	0.1111
p.S334I	DO229024	LICA	ICGC	VGTPQST	DEG_SCF_FBW7_1	0.1111
p.P352H	DO26552	LUSC	ICGC	VGTPQST	DEG_SCF_FBW7_1	0.3333
p.I342M	DO50118	STAD	ICGC	VGTPQST	DEG_SCF_FBW7_1	0.7618
p.P343A	DO229213	THCA	ICGC	VGTPQST	DEG_SCF_FBW7_1	0.7503
p.P349S	DO42177	UCEC	ICGC	VGTPQST	DEG_SCF_FBW7_1	0.3056
p.N336H	SIDM00537	Colorectal Carcinoma	GDSC	VGTPQST	DEG_SCF_FBW7_1	0.1667
p.N336H	ACH-001345	Colon/Colorectal Cancer	CCLE	VGTPQST	DEG_SCF_FBW7_1	0.1667
p.N336H	GP5d	large_intestine	COSMIC	VGTPQST	DEG_SCF_FBW7_1	0.1667
p.D334E	SIDM00863	Burkitt's Lymphoma	GDSC	VGTPQST	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P54274	Telomeric repeat-binding factor 1	DEG_SCF_FBW7_1	342:348	VGTPQST	FBXW7	0.994	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons