DegronMD - P54289(CACNA2D1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K583N	TCGA-17-Z030	LUAD	TCGA	DGESGE	DEG_Kelch_Keap1_1	580:585	Mutation altering degron motif	0.6918
p.K583N	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	DGESGE	DEG_Kelch_Keap1_1	580:585	Mutation altering degron motif	0.6918
p.K583N	ACH-000860	Lung Cancer	CCLE	DGESGE	DEG_Kelch_Keap1_1	580:585	Mutation altering degron motif	0.6918
p.K583N	NCI-H358	lung	COSMIC	DGESGE	DEG_Kelch_Keap1_1	580:585	Mutation altering degron motif	0.6918
p.Y588C	TCGA-BF-AAOX	SKCM	TCGA	DGESGE	DEG_Kelch_Keap1_1	580:585	Mutation rewiring degron network	0.25
p.R570I	TCGA-CA-6717	COAD	TCGA	DGESGE	DEG_Kelch_Keap1_1	580:585	Mutation rewiring degron network	0.0556
p.D577N	TCGA-CQ-7071	HNSC	TCGA	DGESGE	DEG_Kelch_Keap1_1	580:585	Mutation substituting flanking lysine	0.3611
p.D582G	TCGA-D1-A16X	UCEC	TCGA	DGESGE	DEG_Kelch_Keap1_1	580:585	Mutation altering degron motif	0.7198
p.T571N	TCGA-D1-A16X	UCEC	TCGA	DGESGE	DEG_Kelch_Keap1_1	580:585	Mutation substituting flanking lysine	0.1944
p.E578K	TCGA-D3-A8GM	SKCM	TCGA	DGESGE	DEG_Kelch_Keap1_1	580:585	Mutation rewiring degron network	0.2778
p.R570K	TCGA-EB-A6QY	SKCM	TCGA	DGESGE	DEG_Kelch_Keap1_1	580:585	Mutation rewiring degron network	0.0556
p.D577Y	TCGA-EY-A1G8	UCEC	TCGA	DGESGE	DEG_Kelch_Keap1_1	580:585	Mutation substituting flanking lysine	0.3611
p.K577N	DO6254	CESC	ICGC	DGESGE	DEG_Kelch_Keap1_1	580:585	Mutation substituting flanking lysine	0.3611
p.R589I	DO8264	COAD	ICGC	DGESGE	DEG_Kelch_Keap1_1	580:585	Mutation rewiring degron network	0.2222
p.R575Q	DO233240	GACA	ICGC	DGESGE	DEG_Kelch_Keap1_1	580:585	Mutation rewiring degron network	0.1944
p.R575Q	DO48646	SKCM	ICGC	DGESGE	DEG_Kelch_Keap1_1	580:585	Mutation rewiring degron network	0.1944
p.R575Q	Hs939-T	skin	COSMIC	DGESGE	DEG_Kelch_Keap1_1	580:585	Mutation rewiring degron network	0.1944
p.D580H	DO50869	LICA	ICGC	DGESGE	DEG_Kelch_Keap1_1	580:585	Mutation altering degron motif	0.7688
p.G584R	DO25528	LUAD	ICGC	DGESGE	DEG_Kelch_Keap1_1	580:585	Mutation altering degron motif	0.7568
p.I579N	DO49875	LUAD	ICGC	DGESGE	DEG_Kelch_Keap1_1	580:585	Mutation rewiring degron network	0.3056
p.R575L	DO228469	MALY	ICGC	DGESGE	DEG_Kelch_Keap1_1	580:585	Mutation rewiring degron network	0.1944
p.R589K	DO48702	SKCM	ICGC	DGESGE	DEG_Kelch_Keap1_1	580:585	Mutation rewiring degron network	0.2222
p.T590N	DO41799	UCEC	ICGC	DGESGE	DEG_Kelch_Keap1_1	580:585	Mutation rewiring degron network	0.1944
p.Q576K	SIDM00489	Oral Cavity Carcinoma	GDSC	DGESGE	DEG_Kelch_Keap1_1	580:585	Mutation rewiring degron network	0.2222
p.Q576K	ACH-002043	Head and Neck Cancer	CCLE	DGESGE	DEG_Kelch_Keap1_1	580:585	Mutation rewiring degron network	0.2222
p.Q576K	Ca9-22	upper aerodigestive tract	COSMIC	DGESGE	DEG_Kelch_Keap1_1	580:585	Mutation rewiring degron network	0.2222
p.E582G	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	DGESGE	DEG_Kelch_Keap1_1	580:585	Mutation altering degron motif	0.7199
p.Q595K	Ca9-22	upper aerodigestive tract	COSMIC	DGESGE	DEG_Kelch_Keap1_1	580:585	Mutation rewiring degron network	0.0556
p.K571R	GP5d	large intestine	COSMIC	DGESGE	DEG_Kelch_Keap1_1	580:585	Mutation substituting flanking lysine	0.1944

Kaplan plot for CACNA2D1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CACNA2D1

UniProt ID: P54289

Entrez ID: 781

Protein name: Voltage-dependent calcium channel subunit alpha-2/delta-1 (Voltage-gated calcium channel subunit alpha-2/delta-1) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-1; Voltage-dependent calcium channel subunit delta-1]

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for CACNA2D1 in