DegronMD

Uniprot ID: P54289

Source protein: Voltage-dependent calcium channel subunit alpha-2/delta-1

Source gene: CACNA2D1

Class: DEG_Kelch_Keap1_1

Location: 580:585

E3 ligase: KEAP1

DEGRON score: 0.8995

ASA_SCORE: 78.0833

COIL: 0.7462

CONS_SCORE: 0.3537

DSS_SCORE: 0.3707

HELIX: 0.069

FCONS_SCORE: 1.0086

RIG_SCORE: 0.703

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K583N	TCGA-17-Z030	LUAD	TCGA	DGESGE	DEG_Kelch_Keap1_1	0.6918
p.K583N	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	DGESGE	DEG_Kelch_Keap1_1	0.6918
p.K583N	ACH-000860	Lung Cancer	CCLE	DGESGE	DEG_Kelch_Keap1_1	0.6918
p.K583N	NCI-H358	lung	COSMIC	DGESGE	DEG_Kelch_Keap1_1	0.6918
p.Y588C	TCGA-BF-AAOX	SKCM	TCGA	DGESGE	DEG_Kelch_Keap1_1	0.25
p.R570I	TCGA-CA-6717	COAD	TCGA	DGESGE	DEG_Kelch_Keap1_1	0.0556
p.D577N	TCGA-CQ-7071	HNSC	TCGA	DGESGE	DEG_Kelch_Keap1_1	0.3611
p.D582G	TCGA-D1-A16X	UCEC	TCGA	DGESGE	DEG_Kelch_Keap1_1	0.7198
p.T571N	TCGA-D1-A16X	UCEC	TCGA	DGESGE	DEG_Kelch_Keap1_1	0.1944
p.E578K	TCGA-D3-A8GM	SKCM	TCGA	DGESGE	DEG_Kelch_Keap1_1	0.2778
p.R570K	TCGA-EB-A6QY	SKCM	TCGA	DGESGE	DEG_Kelch_Keap1_1	0.0556
p.D577Y	TCGA-EY-A1G8	UCEC	TCGA	DGESGE	DEG_Kelch_Keap1_1	0.3611
p.K577N	DO6254	CESC	ICGC	DGESGE	DEG_Kelch_Keap1_1	0.3611
p.R589I	DO8264	COAD	ICGC	DGESGE	DEG_Kelch_Keap1_1	0.2222
p.R575Q	DO233240	GACA	ICGC	DGESGE	DEG_Kelch_Keap1_1	0.1944
p.R575Q	DO48646	SKCM	ICGC	DGESGE	DEG_Kelch_Keap1_1	0.1944
p.R575Q	Hs939-T	skin	COSMIC	DGESGE	DEG_Kelch_Keap1_1	0.1944
p.D580H	DO50869	LICA	ICGC	DGESGE	DEG_Kelch_Keap1_1	0.7688
p.G584R	DO25528	LUAD	ICGC	DGESGE	DEG_Kelch_Keap1_1	0.7568
p.I579N	DO49875	LUAD	ICGC	DGESGE	DEG_Kelch_Keap1_1	0.3056
p.R575L	DO228469	MALY	ICGC	DGESGE	DEG_Kelch_Keap1_1	0.1944
p.R589K	DO48702	SKCM	ICGC	DGESGE	DEG_Kelch_Keap1_1	0.2222
p.T590N	DO41799	UCEC	ICGC	DGESGE	DEG_Kelch_Keap1_1	0.1944
p.Q576K	SIDM00489	Oral Cavity Carcinoma	GDSC	DGESGE	DEG_Kelch_Keap1_1	0.2222
p.Q576K	ACH-002043	Head and Neck Cancer	CCLE	DGESGE	DEG_Kelch_Keap1_1	0.2222
p.Q576K	Ca9-22	upper_aerodigestive_tract	COSMIC	DGESGE	DEG_Kelch_Keap1_1	0.2222
p.E582G	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	DGESGE	DEG_Kelch_Keap1_1	0.7199
p.Q595K	Ca9-22	upper_aerodigestive_tract	COSMIC	DGESGE	DEG_Kelch_Keap1_1	0.0556
p.K571R	GP5d	large_intestine	COSMIC	DGESGE	DEG_Kelch_Keap1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46100	Transcriptional regulator ATRX	DEG_Kelch_Keap1_1	1349:1354	DGESGE	KEAP1	0.7062	More...
P54289	Voltage-dependent calcium channel subunit alpha-2/delta-1	DEG_Kelch_Keap1_1	580:585	DGESGE	KEAP1	0.8995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DGESGE

Degron related mutations and impact score

Drug responses associated with CACNA2D1 mutations

All proteins holding degron of DGESGE