DegronMD

Uniprot ID: P46100

Source protein: Transcriptional regulator ATRX

Source gene: ATRX

Class: DEG_Kelch_Keap1_1

Location: 1349:1354

E3 ligase: KEAP1

DEGRON score: 0.7062

ASA_SCORE: 91.4167

COIL: 0.8488

CONS_SCORE: 0.2717

DSS_SCORE: 0.6616

HELIX: 0.1402

FCONS_SCORE: 0.9388

RIG_SCORE: 0.5488

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1342W	TCGA-AJ-A3EL	UCEC	TCGA	DGESGE	DEG_Kelch_Keap1_1	0.1389
p.D1349E	TCGA-BR-8366	STAD	TCGA	DGESGE	DEG_Kelch_Keap1_1	0.6758
p.G1350E	TCGA-DU-6392	LGG	TCGA	DGESGE	DEG_Kelch_Keap1_1	0.6087
p.G1350E	DO41871	UCEC	ICGC	DGESGE	DEG_Kelch_Keap1_1	0.6087
p.K1344E	TCGA-FI-A2D0	UCEC	TCGA	DGESGE	DEG_Kelch_Keap1_1	0.3056
p.F1346L	DO4134	BRCA	ICGC	DGESGE	DEG_Kelch_Keap1_1	0.6944
p.R1363Q	DO233790	GACA	ICGC	DGESGE	DEG_Kelch_Keap1_1	0.0833
p.R1363Q	DO43218	UCEC	ICGC	DGESGE	DEG_Kelch_Keap1_1	0.0833
p.P1364S	DO10880	GBM	ICGC	DGESGE	DEG_Kelch_Keap1_1	0.1667
p.S1344Y	DO37543	SKCM	ICGC	DGESGE	DEG_Kelch_Keap1_1	0.3056
p.E1354D	DO229227	THCA	ICGC	DGESGE	DEG_Kelch_Keap1_1	0.6758
p.D1345A	DO40884	UCEC	ICGC	DGESGE	DEG_Kelch_Keap1_1	0.2222
p.S1352C	DO40924	UCEC	ICGC	DGESGE	DEG_Kelch_Keap1_1	0.8652
p.S1352T	DO40924	UCEC	ICGC	DGESGE	DEG_Kelch_Keap1_1	0.7116
p.E1359K	DO41020	UCEC	ICGC	DGESGE	DEG_Kelch_Keap1_1	0.6389
p.R1339M	ACH-000961	Endometrial/Uterine Cancer	CCLE	DGESGE	DEG_Kelch_Keap1_1	0.0556
p.E1353K	MCC13	skin	COSMIC	DGESGE	DEG_Kelch_Keap1_1	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46100	Transcriptional regulator ATRX	DEG_Kelch_Keap1_1	1349:1354	DGESGE	KEAP1	0.7062	More...
P54289	Voltage-dependent calcium channel subunit alpha-2/delta-1	DEG_Kelch_Keap1_1	580:585	DGESGE	KEAP1	0.8995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons